Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewEvofosfamide
说明： Hypoxia-activated DNA alkylating agent prodrug
化学名： (1-Methyl-2-nitro-1H-imidazol-5-yl)methyl N,N'-bis(2-bromoethyl)phosphorodiamidate
纯度： ≥98% (HPLC)
生物活性 for Evofosfamide
Evofosfamide is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). Evofosfamide is stable under normoxic conditions but is activated by cellular reductases in hypoxic conditions (IC50 values are 5.1 μM and 0.019 μM, in NSCLC cells under normoxic and hypoxic conditions, respectively). Br-IPM acts as a DNA alkylating agent, inducing intrastrand and interstrand crosslinks. Evofosfamide inhibits NEPC PDX tumor growth by 84.5% in adeno-CRPC and NEPC patient-derived xenograft models. When combined with gemcitabine (Cat. No. 3259), Evofosfamide inhibits primary tumor growth by 96% and significantly extends the survival time in the MIA PaCa-2 human pancreatic cancer orthotopic xenograft model.
技术数据 for Evofosfamide
| 分子量 | 449.04 |
| 公式 | C9H16Br2N5O4P |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 918633-87-1 |
| PubChem ID | 11984561 |
| InChI Key | UGJWRPJDTDGERK-UHFFFAOYSA-N |
| Smiles | CN1C(COP(NCCBr)(NCCBr)=O)=CN=C1[N+]([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Evofosfamide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 2.25 | 5 | |
| DMSO | 44.9 | 100 |
制备储备液 for Evofosfamide
以下数据基于产品分子量 449.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.23 mL | 11.13 mL | 22.27 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.45 mL |
| 10 mM | 0.22 mL | 1.11 mL | 2.23 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for Evofosfamide
参考文献 for Evofosfamide
参考文献是支持产品生物活性的出版物。
Duan et al (2008) Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J.Med.Chem. 51 2412 PMID: 18257544
Guo et al (2019) ONECUT2 is a driver of neuroendocrine prostate cancer. Nat.Commun. 10 278 PMID: 30655535
If you know of a relevant reference for Evofosfamide, please let us know.
关键词: Evofosfamide, Evofosfamide supplier, hypoxia, activated, prodrug, DNA, crosslink, antitumor, alkylating, agent, phosphoramide, mustard, Cell, Cycle, Inhibitors, Apoptosis, Inducers, 7507, Tocris Bioscience
篇 Evofosfamide 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 Evofosfamide 的引用文献。 您是否知道使用了 Tocris Evofosfamide 的优秀论文？ 请告知我们.
Evofosfamide 的评论
目前没有该产品的评论。 Be the first to review Evofosfamide and earn rewards!
Have you used Evofosfamide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Evofosfamide
