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Submit ReviewFH 535
Discontinued Product
4344 has been discontinued.
说明： Inhibitor of Wnt/β-catenin signaling
化学名： 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
纯度： ≥99% (HPLC)
生物活性 for FH 535
FH 535 is an inhibitor of Wnt/β-catenin signaling and dual antagonist of PPARγ/δ activity. Suppresses β-catenin/Tcf-mediated transcription; inhibits β-catenin and GRIP1 recruitment to PPARγ and δ. Exhibits antiproliferative effects in transformed colon, lung and liver cancer cell lines.
化合物库 for FH 535
FH 535 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for FH 535
| 分子量 | 361.2 |
| 公式 | C13H10Cl2N2O4S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 108409-83-2 |
| PubChem ID | 3463933 |
| InChI Key | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
| Smiles | ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FH 535
参考文献 for FH 535
参考文献是支持产品生物活性的出版物。
Handeli and Simon (2008) A small-molecule inhibitor of Tcf/β-catenin signaling down-regulates PPARγ and PPARδ activities. Mol.Cancer Ther. 7 521 PMID: 18347139
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关键词: FH 535, FH 535 supplier, FH535, wnt, beta-catenin, inhibitors, inhibits, bcat, bcatenin, TCFPPARg, PPARd, PPARgamma, PPARdelta, peroxisome, proliferator-activated, receptor, antagonist, Beta-catenin, Receptors, 4344, Tocris Bioscience
4 篇 FH 535 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FH 535 的部分引用包括：
Stefan et al (2022) The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function. Eur Respir J 59 PMID: 34561292
Qunyuan et al (2018) Insulin-like growth factor binding protein 4 inhibits proliferation of bone marrow mesenchymal stem cells and enhances growth of neurospheres derived from the stem cells. Cell Biochem Funct 36 331-341 PMID: 30028031
Lan et al (2017) Live cell screening platform identifies PPARδ as a regulator of cardiomyocyte proliferation and cardiac repair. Cell Res 27 1002-1019 PMID: 28621328
Craig B et al (2017) Metabolic origins of spatial organization in the tumor microenvironment. Proc Natl Acad Sci U S A 114 2934-2939 PMID: 28246332
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