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FITC-CHIPOpt

Cat. No. 8045 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluorescent CHIP/STUB1 E3 ligase inhibitor
纯度： ≥95% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FITC-CHIPOpt

FITC-CHIPOpt is a fluorescent CHIP/STUB1 E3 ligase inhibitor. It binds to CHIP and can be used in CHIP fluorescent polarization (FP) binding assays. Enables CHIP FP binding assays to be developed for new inhibitor or CHIP ligand synthesis. FITC-CHIPOpt is the fluorescent version of CHIPOp (Cat. No. 8044).

技术数据 for FITC-CHIPOpt

分子量 1218.35
公式 C64H67N9O14S
序列 XLWWPD

(Modifications: X-1 = FTIC-6-aminohexanoic acid
储存 Store at -20°C
纯度 ≥95% (HPLC)
InChI Key WHLHAYSAZOFWTL-TVKYAJOTSA-N
Smiles O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)[C@H](CC(C)C)NC(CCCCCNC(NC(C=C6C(O)=O)=CC=C6C(C7=C8C=C(O)C=C7)=C(C=C9)C(O8)=CC9=O)=S)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FITC-CHIPOpt

溶解性 Soluble to 1 mg/ml in PBS

参考文献 for FITC-CHIPOpt

参考文献是支持产品生物活性的出版物。

Nadel et al (2023) The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 435 168026 PMID: 37330289

Ravalin et al (2019) Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 15 786 PMID: 31320752

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关键词: FITC-CHIPOpt, FITC-CHIPOpt supplier, FITCCHIPOpt, fluorescent, polarization, binding, assays, ubiquitin, ligase, inhibitor, inhibitors, inhibit, ligases, ubiquitination, in, vitro, phosphorylated, tau, aggregation, Other, Fluorescent, Probes, Ubiquitin, E3, Ligases, 8045, Tocris Bioscience

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Fluorescent Dyes and Probes Research Product Guide

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