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Description: CHIP/STUB1 E3 ligase inhibitor
Purity: ≥95% (HPLC)
Biological Activity for CHIPOpt
CHIPOpt is a CHIP/STUB1 E3 ligase inhibitor. In vitro, CHIPOpt decreases phosphorylated tau ubiquitination, with little effect on unmodified tau. In Thioflavin T assays, CHIPOpt inhibits the ability of CHIP to suppress phosphorylated tau aggregation. FITC-CHIPOpt (Cat. No. 8045), a fluorescent CHIPOpt, is also available.
Technical Data for CHIPOpt
| M. Wt | 757.84 |
| Formula | C39H47N7O9 |
| Sequence |
LWWPD (Modification: Leu-1 = N-terminal Ac) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | NAUYSEKQVONAJC-ZTTXAYQISA-N |
| Smiles | O=C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N5[C@@H](CCC5)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CHIPOpt
| Solubility | Soluble to 2 mg/ml in 0.01M PBS |
Product Datasheets for CHIPOpt
References for CHIPOpt
References are publications that support the biological activity of the product.
Nadel et al (2023) The E3 ubiquitin ligase, CHIP/STUB1, inhibits aggregation of phosphorylated proteoforms of microtubule-associated protein tau (MAPT). J.Mol.Biol. 435 168026 PMID: 37330289
Ravalin et al (2019) Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat.Chem.Biol. 15 786 PMID: 31320752
If you know of a relevant reference for CHIPOpt, please let us know.
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Keywords: CHIPOpt, CHIPOpt supplier, CHIPOpt, ubiquitin, ligase, inhibitor, inhibitors, inhibit, ligases, ubiquitination, in, vitro, phosphorylated, tau, aggregation, Ubiquitin, E3, Ligases, 8044, Tocris Bioscience
Citations for CHIPOpt
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Literature in this Area
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TPD and Induced Proximity Research Product GuideUpdated
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia