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FM19G11

Cat. No. 6653 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： HIF α-subunit inhibitor
化学名： 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FM19G11

FM19G11 is a hypoxia inducible factor (HIF) α-subunit inhibitor (IC50 = 80 nM in hypoxia induced luciferase assay). Inhibits transcriptional activity of HIFα isoforms. Directly regulates expression and inhibits transcriptional activity of pluripotency markers (Sox2 and Oct4) in rodent and human stem cells under hypoxic conditions, driving differentiation. Improves locomotion after severe spinal cord injury in mice, alone or in combination with transplantation of ependymal stem cells of the spinal cord. Also inhibits O6-methylguanine DNA methyltransferase (MGMT) via HIF1α pathway, under normal and hypoxic conditions in glioblastoma cell lines.

化合物库 for FM19G11

FM19G11 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Epigenetics Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for FM19G11

分子量 463.4
公式 C23H17N3O8
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 329932-55-0
PubChem ID 1730746
InChI Key XVUOIWIIQVGWAJ-UHFFFAOYSA-N
Smiles CC1=CC=C(C(COC(C2=CC=CC(NC(C3=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C3)=O)=C2)=O)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FM19G11

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.34 100

制备储备液 for FM19G11

以下数据基于产品分子量 463.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.16 mL 10.79 mL 21.58 mL
5 mM 0.43 mL 2.16 mL 4.32 mL
10 mM 0.22 mL 1.08 mL 2.16 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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参考文献 for FM19G11

参考文献是支持产品生物活性的出版物。

Moreno-Manzano et al (2010) FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J.Biol.Chem. 285 1333 PMID: 19897487

Alastrue-Agudo et al (2018) FM19G11 and ependymal progenitor/stem cell combinatory treatment enhances neuronal preservation and oligodendrogenesis after severe spinal cord injury. Int.J.Mol.Sci. 19 E200 PMID: 29315225

You et al (2018) FM19G11 inhibits O6-methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 7 3292 PMID: 29761922

If you know of a relevant reference for FM19G11, please let us know.

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关键词: FM19G11, FM19G11 supplier, hypoxia, inducible, factor, alpha, subunit, HIF1a, HIF2a, HIF3a, inhibits, inhibitors, pluripotency, genes, stemness, Hypoxia, Inducible, Factors, Other, Differentiation, Products, 6653, Tocris Bioscience

篇 FM19G11 的引用文献

引用文献是使用了 Tocris 产品的出版物。

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FM19G11 的评论

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good product, satisfied.
By Kishor Pant on 02/17/2020
分析类型： In Vitro
种属： Human
细胞系/组织： Hepg2, Huh7

Used this in 100nM for 24 hours in cultured cells and inhibited HIF1 level in the cells (checked by western blotting)

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