主页 / 药理学 / Enzymes / Kinases / RSK / RSK Inhibitors / Fmk

Fmk

Cat. No. 4690 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4690 has been discontinued.

View all RSK products.
说明： Irreversible ribosomal S6 kinase 1/2 inhibitor
化学名： 1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone
纯度： ≥97% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Fmk

Fmk is a potent irreversible RSK1/2 inhibitor (IC50 = 15 nM). Inactivates the C-terminal auto-kinase domain activity. Suppresses RSK2 kinase activity in RSK2-expressing HNSCC cell lines. Reduces HNSCC cell invasive ability. Displays no effect on EGF-stimulated phosphorylation of ERK1 or ERK2.

技术数据 for Fmk

分子量 342.37
公式 C18H19FN4O2
储存 Store at -20°C
纯度 ≥97% (HPLC)
CAS Number 821794-92-7
PubChem ID 644243
InChI Key IKLGYJACVCXYIL-UHFFFAOYSA-N
Smiles O=C(CF)C2=C(C3=CC=C(C)C=C3)C1=C(N)N=CN=C1N2CCCO

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Fmk

参考文献是支持产品生物活性的出版物。

Cohen et al (2005) Structural bioinformatics-based design of selective, irreversible kinase inhibitors. Science 308 1318 PMID: 15919995

Cohen et al (2007) A clickable inhibitor reveals context-dependent autoactivation of p90 RSK. Nat.Chem.Biol. 3 156 PMID: 17259979

Kang et al (2010) p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells. J.Clin.Invest. 120 1165 PMID: 20234090

按标靶查看相关产品

按产品操作查看相关产品

查看全部 RSK Inhibitors

关键词: Fmk, Fmk supplier, RSK-FMK, Irreversible, RSK1, RSK2, inhibitors, inhibits, p90, ribosomal, protein, S6, kinases, potent, RSK, 4690, Tocris Bioscience

篇 Fmk 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Fmk 的引用文献。

Fmk 的评论

目前没有该产品的评论。 Be the first to review Fmk and earn rewards!

Have you used Fmk?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review