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说明： GSK-3 inhibitor
生物活性 for FRATide
Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalyzed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B.
技术数据 for FRATide
| 分子量 | 4534.11 |
| 公式 | C192H327N67O60 |
| 序列 | SQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQ |
| 储存 | Desiccate at -20°C |
| CAS Number | 251087-38-4 |
| Smiles | [H]N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
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产品说明书 for FRATide
参考文献 for FRATide
参考文献是支持产品生物活性的出版物。
Bax et al (2001) The structure of phosphorylated GSK-3β complexed with peptide, FRATtide, that inhibits α-catenin phosphorylation. Structure 9 1143 PMID: 11738041
Thomas et al (1999) A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and α-catenin FEBS Lett. 458 247 PMID: 10481074
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关键词: FRATide, FRATide supplier, GSK-3, inhibitors, inhibits, Glycogen, Synthase, Kinase, 3, inhibitor, Carbohydrate, Metabolism, 1835, Tocris Bioscience
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