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Glycyl-H 1152 dihydrochloride

Cat. No. 2485 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414)
化学名： (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (3)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Glycyl-H 1152 dihydrochloride

Glycyl-H 1152 dihydrochloride is a glycyl analog of the Rho-kinase inhibitor H 1152 dihydrochloride (Cat. No. 2414) that displays improved ROCKII selectivity. IC50 values are 0.0118, 2.35, 2.57, 3.26, > 10 and >10 μM for ROCKII, Aurora A, CAMKII, PKG, PKA and PKC respectively.

技术数据 for Glycyl-H 1152 dihydrochloride

分子量 449.4
公式 C18H24N4O3S.2HCl
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 913844-45-8
PubChem ID 56972177
InChI Key ILDBNQGLZFSHQZ-UTLKBRERSA-N
Smiles CC1=CN=CC2=C1C(S(N3CCCN(C(CN)=O)C[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Glycyl-H 1152 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 44.94 100
DMSO 22.47 50

制备储备液 for Glycyl-H 1152 dihydrochloride

以下数据基于产品分子量 449.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.23 mL 11.13 mL 22.25 mL
5 mM 0.45 mL 2.23 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.23 mL
50 mM 0.04 mL 0.22 mL 0.45 mL

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产品说明书 for Glycyl-H 1152 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Glycyl-H 1152 dihydrochloride

参考文献是支持产品生物活性的出版物。

Tamura et al (2005) Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 1754 245 PMID: 16213195

If you know of a relevant reference for Glycyl-H 1152 dihydrochloride, please let us know.

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关键词: Glycyl-H-1152 dihydrochloride, Glycyl-H-1152 dihydrochloride supplier, selective, Rho-Associated, Coiled-Coil, Kinases, ROCK, p160ROCK, ROK, Rho-Kinases, Rho-kinases, 2485, Tocris Bioscience

4 篇 Glycyl-H 1152 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Glycyl-H 1152 dihydrochloride 的部分引用包括：

Siegel et al (2010) Contribution of human amniotic fluid stem cells to renal tissue formation depends on mTOR. Hum Mol Genet 19 3320 PMID: 20542987

Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. PLoS One 85 173 PMID: 25569349

Sadaie et al (2015) Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell 26 2971 PMID: 26133385

Lawrence et al (2015) Transport of organic anions and cations in murine embryonic kidney development and in serially-reaggregated engineered kidneys. Sci Rep 5 9092 PMID: 25766625

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