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GN 44028

Cat. No. 5655 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent HIF-1α inhibitor
化学名： N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GN 44028

GN 44028 is a potent HIF-1α inhibitor (IC50 = 14 nM). Inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. Cytotoxic to a range of cancer cell types in vitro.

化合物库 for GN 44028

GN 44028 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GN 44028

分子量 305.33
公式 C18N15N3O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1421448-26-1
PubChem ID 71625259
InChI Key CGZKSZVSWAAUHE-UHFFFAOYSA-N
Smiles C12=CC=CC=C1C3=C(C(NC4=CC(OCCO5)=C5C=C4)=NN3)C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GN 44028

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.53 100
ethanol 30.53 100

制备储备液 for GN 44028

以下数据基于产品分子量 305.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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产品说明书 for GN 44028

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for GN 44028

参考文献是支持产品生物活性的出版物。

Minegishi et al (2013) Discovery of indenopyrazoles as a new class of hypoxia inducible factor (HIF)-1 inhibitors. ACS Med.Chem.Lett. 4 297 PMID: 24900662

If you know of a relevant reference for GN 44028, please let us know.

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关键词: GN 44028, GN 44028 supplier, GN44028, HIF-1a, HIF-1alpha, HIF-1α, inhibitors, hypoxia-inducible, factors, inhibits, cytotoxic, Hypoxia, Inducible, Factors, 5655, Tocris Bioscience

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