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GNF 2

Cat. No. 4399 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4399 has been discontinued.

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说明： Selective allosteric inhibitor of Bcr-Abl tyrosine kinase activity
化学名： 3-[6-[[4-(Trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide
纯度： ≥98% (HPLC)
说明书
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生物活性 技术数据 说明书 参考文献

生物活性 for GNF 2

GNF 2 is an allosteric inhibitor of Bcr-Abl tyrosine kinase activity (IC50 = 267 nM); inhibits proliferation and induces apoptosis in Bcr-Abl-expressing cells. Selective for Bcr-Abl over a panel of serine, threonine and tyrosine kinases. Non-ATP-competitive.

技术数据 for GNF 2

分子量 374.32
公式 C18H13F3N4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 778270-11-4
PubChem ID 5311510
InChI Key WEVYNIUIFUYDGI-UHFFFAOYSA-N
Smiles NC(C1=CC(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)=CC=C1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for GNF 2

参考文献是支持产品生物活性的出版物。

Zhang et al (2010) Targeting Bcr-Abl by combining allosteric with ATP-binding site inhibitors. Nature 463 501 PMID: 20072125

Adrián et al (2006) Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat.Chem.Biol. 2 95 PMID: 16415863

Ohren & Sebolt-Leopold et al (2006) Inhibitors of Bcr-abl... breaking new ground again. Nat.Chem.Biol. 2 63 PMID: 16421581

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