Go 6976

Cat. No. 2253 16 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent protein kinase C inhibitor; selective for α and β isozymes

化学名： 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile

纯度： ≥95% (HPLC)

说明书

引用文献 (16)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Go 6976

Go 6976 is a potent protein kinase C (PKC) inhibitor (IC₅₀ = 7.9 nM). Discriminates between Ca²⁺-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC₅₀ values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC₅₀ > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC₅₀ values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint.

技术数据 for Go 6976

分子量	378.43
公式	C₂₄H₁₈N₄O
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	136194-77-9
PubChem ID	3501
InChI Key	VWVYILCFSYNJHF-UHFFFAOYSA-N
Smiles	O=C(NC3)C1=C3C(C4=CC=CC=C4N5CCC#N)=C5C2=C1C6=C(C=CC=C6)N2C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Go 6976

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.78	10

制备储备液 for Go 6976

以下数据基于产品分子量 378.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	26.42 mL	132.12 mL	264.25 mL
0.5 mM	5.28 mL	26.42 mL	52.85 mL
1 mM	2.64 mL	13.21 mL	26.42 mL
5 mM	0.53 mL	2.64 mL	5.28 mL

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产品说明书 for Go 6976

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Go 6976

参考文献是支持产品生物活性的出版物。

Martiny-Baron et al (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976 J.Biol.Chem. 268 9194 PMID: 8486620

Rennecke et al (1996) Immunological demonstration of protein kinase Cμ in murine tissues and various cell lines. Eur.J.Biochem. 242 428 PMID: 8973662

Behrens et al (1999) Go 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase. J.Neurochem. 72 919 PMID: 10037462

Grandage et al (2006) Go6976 is a potent inhibitor of JAK2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells. Br.J.Haematol. 135 303 PMID: 16956345

Stolz et al (2009) Pharmacologic abrogation of the mitotic spindle checkpoint by an indolocarbazole discovered by cellular screening efficiently kills cancer cells. Cancer Res. 69 3874 PMID: 19366805

If you know of a relevant reference for Go 6976, please let us know.

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