Go 6983

Cat. No. 2285 25 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Broad spectrum PKC inhibitor

别名： Goe 6983

化学名： 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

纯度： ≥98% (HPLC)

说明书

引用文献 (25)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Go 6983

Go 6983 is a broad spectrum protein kinase C (PKC) inhibitor (IC₅₀ values are 7, 7, 6, 10, 60 and 20000 nM for PKCα, PKCβ, PKCγ, PKCδ, PKCζ and PKCμ respectively). Displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia/reperfusion injury. Optimizes naïve human pluripotent stem cell growth and viability following naïve cell derivation from primed ESCs and iPSCs using naïve human stem cell medium (NHSM).

技术数据 for Go 6983

分子量	442.51
公式	C₂₆H₂₆N₄O₃
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	133053-19-7
PubChem ID	3499
InChI Key	LLJJDLHGZUOMQP-UHFFFAOYSA-N
Smiles	O=C(N1)C(C2=CNC3=C2C=CC=C3)=C(C4=CN(CCCN(C)C)C5=C4C=C(OC)C=C5)C1=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Go 6983

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.12	50

制备储备液 for Go 6983

以下数据基于产品分子量 442.51。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.52 mL	22.6 mL	45.2 mL
2.5 mM	0.9 mL	4.52 mL	9.04 mL
5 mM	0.45 mL	2.26 mL	4.52 mL
25 mM	0.09 mL	0.45 mL	0.9 mL

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产品说明书 for Go 6983

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Go 6983

参考文献是支持产品生物活性的出版物。

Gschwendt et al (1996) Inhibition of protein kinase C μ by various inhibitors. Differentiation from protein kinase c isozymes. FEBS Lett. 392 77 PMID: 8772178

Peterman et al (2004) Go 6983 exerts cardioprotective effects in myocardial ischemic/reperfusion. J.Cardiovasc.Pharmacol. 43 645 PMID: 15071351

Young et al (2005) Go 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc.Drug Rev. 23 255 PMID: 16252018

Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504 282 PMID: 24172903

If you know of a relevant reference for Go 6983, please let us know.

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关键词: Go 6983, Go 6983 supplier, Broad, spectrum, PKC, inhibitors, inhibits, Protein, Kinases, C, Go6983, Goe6983, stem, cells, naive, Goe, 6983, Kinase, Stem, Cell, Proliferation, 2285, Tocris Bioscience

25 篇 Go 6983 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Go 6983 的部分引用包括：

Schaffer et al (2018) PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep 25 2470 PMID: 30485813

Li et al (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. J Clin Invest 126 389 PMID: 26657863

Devinney et al (2015) Phrenic long-term facilitation requires PKCθ activity within phrenic motor neurons. Proc Natl Acad Sci U S A 35 8107 PMID: 26019328

Shakiba et al (2015) CD24 tracks divergent pluripotent states in mouse and human cells. J Biol Chem 6 7329 PMID: 26076835

Scarisbrick et al (2012) Kallikrein 6 is a novel molecular trigger of reactive astrogliosis. Front Cell Neurosci 393 355 PMID: 22505518

Garrett et al (2012) γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway. PLoS One 74 269 PMID: 22542181

Liu et al (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Transl Psychiatry 8 232 PMID: 30352990

Fang et al (2018) A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells. Nat Commun 9 4384 PMID: 30349051

Augustin et al (2017) Reduced ins. signaling maintains electrical transmission in a neural circuit in aging flies. PLoS Biol 15 e2001655 PMID: 28902870

Zhang et al (2017) Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med 214 2671 PMID: 28716882

Yi et al (2014) Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. Neuron 289 30101 PMID: 25124035

Kuan et al (2014) Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway. Biol Chem 9 e113485 PMID: 25490397

Cavaliere et al (2014) NMDA modulates oligodendrocyte differentiation of subventricular zone cells through PKC activation. Cell Signal 7 261 PMID: 24391542

Atwood et al (2013) GLI activation by atypical protein kinase C Ι/λ regulates the growth of basal cell carcinomas. J Neurosci 494 484 PMID: 23446420

Dutta et al (2011) Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance. Stem Cells 29 618 PMID: 21308862

Messmer et al (2019) Transcriptional Heterogeneity in Naive and Primed Human Pluripotent Stem Cells at Single-Cell Resolution. Cell Rep 26 815 PMID: 30673604

Carriba (2017) CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. Elife 6 PMID: 29111976

Toda and Huganir (2015) Regulation of AMPA receptor phosphorylation by the neuropeptide PACAP38. Nat Commun 112 6712 PMID: 25964356

Pakpour et al (2013) Protein kinase C-dependent signaling controls the midgut epithelial barrier to malaria parasite infection in anopheline mosquitoes. PLoS One 8 e76535 PMID: 24146884

Vliet et al (2013) Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL). J Biol Chem 288 27519 PMID: 23918927

Rajendran et al (2013) Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency. J Biol Chem 288 24351 PMID: 23846691

Rostovskaya et al (2019) Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development 146 PMID: 30944104

Mclaurin and Weiner (2019) Multiple sources of signal amplification within the B-cell Ras/MAPK pathway. Mol Biol Cell 30 1610 PMID: 31042097

Tuvikene et al (2016) AP-1 Transcription Factors Mediate BDNF-Positive Feedback Loop in Cortical Neurons. J Neurosci 36 1290 PMID: 26818516

Baskin and Sayeski (2012) Angiotensin II mediates cell survival through upregulation and activation of the serum and glucocorticoid inducible kinase 1. BMC Complement Altern Med 24 435 PMID: 21963429

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Go 6983 blocks LPA-mediated COX-2 expression.

By Anonymous on 12/13/2018

分析类型： In Vitro

种属： Human

细胞系/组织： Osteosarcoma

Human osteosarcoma cells were incubated with 20 μM Go 6983 for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Go 6983 abolished LPA-induced COX-2 expression.

Naive human pluripotent stem cell culture.

By Anonymous on 05/31/2018