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Gossypol

Cat. No. 1964 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Proapoptotic; downregulates Bcl-2 and Bcl-XL
化学名： 1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (2)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Gossypol

Gossypol is a lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL.

R-enantiomer also available.

技术数据 for Gossypol

分子量 518.56
公式 C30H30O8
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 303-45-7
PubChem ID 3503
InChI Key QBKSWRVVCFFDOT-UHFFFAOYSA-N
Smiles CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(=C(C)C=C12)C1=C(O)C2=C(C=O)C(O)=C(O)C(C(C)C)=C2C=C1C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gossypol

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 12.96 25 温和加热
DMSO 12.96 25

制备储备液 for Gossypol

以下数据基于产品分子量 518.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.25 mM 7.71 mL 38.57 mL 77.14 mL
1.25 mM 1.54 mL 7.71 mL 15.43 mL
2.5 mM 0.77 mL 3.86 mL 7.71 mL
12.5 mM 0.15 mL 0.77 mL 1.54 mL

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产品说明书 for Gossypol

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Gossypol

参考文献是支持产品生物活性的出版物。

Coutinh (2002) Gossypol: a contraceptive for men. Contraception 65 259 PMID: 12020773

Vander Jagt et al (2000) Gosspyol: prototype of inhibitors targeted to dinucleotide folds. Curr.Med.Chem. 7 479 PMID: 10702620

Zhang et al (2003) Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem.Pharmacol. 66 93 PMID: 12818369

If you know of a relevant reference for Gossypol, please let us know.

按标靶查看相关产品

关键词: Gossypol, Gossypol supplier, Pro-apoptotic, downregulates, Bcl-2, Bcl-XL, Bax, Mcl-1, Family, 1964, Tocris Bioscience

3 篇 Gossypol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Gossypol 的部分引用包括：

Hsiao et al (2012) Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Mol Vis 18 2033 PMID: 22876131

Mani et al (2015) Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). PLoS One 15 224 PMID: 25885284

Pang et al (2011) (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. Mol Cancer Ther 10 795 PMID: 21372225

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Gossypol 的评论

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该领域的文献

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