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GSK 1059615

Cat. No. 4026 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4026 has been discontinued.

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说明： Potent PI 3-kinase inhibitor
化学名： 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for GSK 1059615

GSK 1059615 is a potent inhibitor of PI 3-kinase α (PI3Kα) (IC50 = 2 nM). Inhibits proliferation in BT474 cells and attenuates MAPK signaling.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

技术数据 for GSK 1059615

分子量 333.36
公式 C18H11N3O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 958852-01-2
PubChem ID 23582824
InChI Key QDITZBLZQQZVEE-YBEGLDIGSA-N
Smiles O=C(/C(S4)=C/C1=CC=C2C(C(C3=CC=NC=C3)=CC=N2)=C1)NC4=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for GSK 1059615

参考文献是支持产品生物活性的出版物。

Saadia et al (2009) Phosphatidylinositol-3-kinase as a therapeutic target in melanoma. Clin.Cancer Res. 15 3029 PMID: 19383818

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39

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关键词: GSK 1059615, GSK 1059615 supplier, Potent, inhibitors, inhibits, PI3Kα, PI3Ka, PI3Kalpha, PI3Kinasealpha, GSK1059615, PI3-kinases, phosphoinositide, 3, kinases, PI, 3-Kinase, 4026, Tocris Bioscience

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