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GSK 2256098

Cat. No. 7786 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent focal adhesion kinase (FAK) inhibitor
化学名： 2-[[5-Chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxybenzamide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 2256098

GSK 2256098 is a potent, reversible and ATP-competitive focal adhesion kinase (FAK) inhibitor (IC50 values are 8.5 nM, 12 nM and 15 nM in U87MG, A549 and OVCAR8 cell lines respectively). Inhibits Y397 phosphorylation and motility, growth and survival of pancreatic ductal adenocarcinoma cells.

技术数据 for GSK 2256098

分子量 414.89
公式 C20H23ClN6O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1224887-10-8
PubChem ID 46214930
InChI Key BVAHPPKGOOJSPU-UHFFFAOYSA-N
Smiles O=C(C1=C(NC2=CC(NC3=CC(C)=NN3C(C)C)=NC=C2Cl)C=CC=C1)NOC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 2256098

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.49 100
ethanol 20.74 50

制备储备液 for GSK 2256098

以下数据基于产品分子量 414.89。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.05 mL 24.1 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.21 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for GSK 2256098

参考文献是支持产品生物活性的出版物。

Zhang et al (2014) A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle 13 3143 PMID: 25486573

If you know of a relevant reference for GSK 2256098, please let us know.

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关键词: GSK 2256098, GSK 2256098 supplier, GSK2256098, focal, adhesion, kinase, FAK, inhibitors, inhibition, inhibit, inhibits, PTK2, protein, tyrosine, Y397, phorphorylation, PDAC, pancreatic, ductal, adenocarcinoma, Focal, Adhesion, Kinase, 7786, Tocris Bioscience

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