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Submit ReviewGSK 6853
说明： Potent and selective BRPF1 inhibitor
化学名： N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide
纯度： ≥98% (HPLC)
生物活性 for GSK 6853
GSK 6853 is a potent and selective BRPF1 inhibitor. Exhibits >1600-fold selectivity for BRPF1 over other bromodomains (pIC50 values by TR-FRET are 8.1, 5.1/4.8 and 4.7/<4.3 for BRPF1, BRPF2/3 and BRD4 BD1/2, respectively).
Negative Control also available.
许可信息
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK 6853 probe summary on the SGC website.
化合物库 for GSK 6853
GSK 6853 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for GSK 6853
| 分子量 | 409.48 |
| 公式 | C22H27N5O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1910124-24-1 |
| PubChem ID | 121232405 |
| InChI Key | FQWDVNSBYDXPIO-CQSZACIVSA-N |
| Smiles | COC1=C(C(NC2=C(N3CCNC[C@H]3C)C=C4N(C(N(C4=C2)C)=O)C)=O)C=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GSK 6853
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.95 | 100 | |
| 1eq. HCl | 40.95 | 100 |
制备储备液 for GSK 6853
以下数据基于产品分子量 409.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.44 mL | 12.21 mL | 24.42 mL |
| 5 mM | 0.49 mL | 2.44 mL | 4.88 mL |
| 10 mM | 0.24 mL | 1.22 mL | 2.44 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.49 mL |
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产品说明书 for GSK 6853
参考文献 for GSK 6853
参考文献是支持产品生物活性的出版物。
Bamborough et al (2016) GSK6853, a chemical probe for inhibition of the BRPF1 bromodomain. ACS Med.Chem.Lett. 7 552 PMID: 27326325
If you know of a relevant reference for GSK 6853, please let us know.
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关键词: GSK 6853, GSK 6853 supplier, GSK6853, bromodomains, BRPF1, inhibitors, inhibits, potent, selective, Bromodomains, 6198, Tocris Bioscience
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