H 1152 dihydrochloride

Name: H 1152 dihydrochloride
Brand: Tocris Bioscience
SKU: 2414
Rating: 5 (1 reviews)

Cat. No. 2414 16 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective Rho-kinase (ROCK) inhibitor

化学名： (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (16)

文献 (3)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for H 1152 dihydrochloride

H 1152 dihydrochloride is a rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC₅₀ values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μM for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC₅₀ = 190 nM) and displays proerectile effects in rats.

Glycyl Derivative also available.

技术数据 for H 1152 dihydrochloride

分子量	392.34
公式	C₁₆H₂₁N₃O₂S.2HCl
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	871543-07-6
PubChem ID	11560225
InChI Key	BFOPDSJOLUQULZ-GXKRWWSZSA-N
Smiles	CC1=CN=CC2=C1C(S(N3CCCNC[C@@H]3C)(=O)=O)=CC=C2.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for H 1152 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	39.23	100
	DMSO	19.62	50

制备储备液 for H 1152 dihydrochloride

以下数据基于产品分子量 392.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.74 mL	25.49 mL
5 mM	0.51 mL	2.55 mL	5.1 mL
10 mM	0.25 mL	1.27 mL	2.55 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for H 1152 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for H 1152 dihydrochloride

参考文献是支持产品生物活性的出版物。

Shum et al (2003) Involvement of Rho-kinase in contraction of guinea-pig aorta induced by prostanoid EP₃ receptor agonist. Br.J.Pharmacol. 139 1449 PMID: 12922932

Teixeira et al (2005) Proerectile effects of the rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine (H-1152) in the rat penis. J.Pharmacol.Exp.Ther. 315 155 PMID: 15976017

Tamura et al (2005) Development of specific Rho-kinase inhibitors and their clinical application. Biochim.Biophys.Acta 1754 245 PMID: 16213195

If you know of a relevant reference for H 1152 dihydrochloride, please let us know.

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关键词: H 1152 dihydrochloride, H 1152 dihydrochloride supplier, Selective, Rho-kinase, ROCK, inhibitors, inhibits, Rho-Kinase, Rho-Associated, Coiled-Coil, Kinases, p160ROCK, ROK, H1152, dihydrochloride, Rho-kinases, 2414, Tocris Bioscience

16 篇 H 1152 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 H 1152 dihydrochloride 的部分引用包括：

Rath et al (2018) Rho Kinase Inhibition by AT13148 Blocks Pancreatic Ductal Adenocarcinoma Invasion and Tumor Growth. Cancer Res 78 3321 PMID: 29669760

Pitha et al (2018) Rho-Kinase Inhibition Reduces Myofibroblast Differentiation and Proliferation of Scleral Fibroblasts Induced by Transforming Growth Factor β and Experimental Glaucoma. Transl Vis Sci Technol 7 6 PMID: 30479877

Sero et al (2015) Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Mol Syst Biol 11 790 PMID: 25735303

Berenjeno et al (2017) Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nat Commun 8 1773 PMID: 29170395

Kramár et al (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Clin Pharmacol 29 12982 PMID: 19828812

Schipper et al (2019) Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin. Nat Commun 10 3800 PMID: 31444332

García-Morales et al (2019) Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1. Nat Commun 10 3784 PMID: 31439839

Sero et al (2015) Cell shape and the microenvironment regulate nuclear translocation of NF-κB in breast epithelial and tumor cells. Mol Syst Biol 11 790 PMID: 26148352

Augspach et al (2013) Activation of RhoA,B,C by Yersinia Cytotoxic Necrotizing Factor (CNFy) induces apoptosis in LNCaP prostate cancer cells. Toxins (Basel) 5 2241 PMID: 24284827

Messal et al (2019) Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature 566 126 PMID: 30700911

Sero and Bakal (2017) Multiparametric Analysis of Cell Shape Demonstrates that β-PIX Directly Couples YAP Activation to Extracellular Matrix Adhesion. Cell Syst 4 84 PMID: 28065575

Durkin et al (2017) RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6. Dev Cell 41 315 PMID: 28486133

Rath et al (2017) ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth. EMBO Mol Med 9 198 PMID: 28031255

Gilsbach et al (2012) Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations. Proc Natl Acad Sci U S A 109 10322 PMID: 22689969

Zenker et al (2018) Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation. Cell 173 776 PMID: 29576449

Aoun et al (2016) Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace)-stimulated Diarrhea: AN ESSENTIAL ROLE FOR PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE (PIP2) SIGNALING IN CHOLERA. J Biol Chem 291 26816 PMID: 27799301

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Filter by:

H1152 for spiral ganglion neuron differentiation.

By Minjin Jeong on 08/09/2019

分析类型： In Vitro

种属： Human

细胞系/组织： iPSCs

H1152 is used for spiral ganglion neuron differentiation.

H1152 is slightly better than Y27632 for neuronal differentiation.

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