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Submit ReviewHA 1100 hydrochloride
说明： Cell-permeable, selective Rho-kinase inhibitor
别名： Hydroxyfasudil
化学名： 1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for HA 1100 hydrochloride
HA 1100 hydrochloride is a cell-permeable active metabolite of Fasudil (HA 1077; Cat. No. 0541). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo.
技术数据 for HA 1100 hydrochloride
| 分子量 | 343.83 |
| 公式 | C14H17N3O3S.HCl |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 155558-32-0 |
| PubChem ID | 11371328 |
| InChI Key | XWWFOUVDVJGNNG-UHFFFAOYSA-N |
| Smiles | Cl.OC1=NC=CC2=C(C=CC=C12)S(=O)(=O)N1CCCNCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HA 1100 hydrochloride
参考文献 for HA 1100 hydrochloride
参考文献是支持产品生物活性的出版物。
Arai et al (1993) Inhibition by the protein kinase inhibitor HA1077 of the activation of NADPH oxidase in human neutrophils. Biochem.Pharmacol. 46 1487 PMID: 8240400
Shimokawa et al (1999) Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc.Res. 43 1029 PMID: 10615430
Utsunomiya et al (2001) Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. Br.J.Pharmacol. 134 1724 PMID: 11739249
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关键词: HA 1100 hydrochloride, HA 1100 hydrochloride supplier, Cell-permeable, selective, Rho-kinase, inhibitors, inhibits, Rho-Associated, Coiled-Coil, Kinases, p160ROCK, ROK, Rho-Kinase, HA1100, hydrochloride, Hydroxyfasudil, Rho-kinases, 2415, Tocris Bioscience
2 篇 HA 1100 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HA 1100 hydrochloride 的部分引用包括：
Pearn et al (2012) PropF. neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology 116 352 PMID: 22198221
Kirschstein et al (2014) Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin 35 74 PMID: 24122009
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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