HJC 0416 hydrochloride

Cat. No. 6110 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： STAT3 inhibitor

化学名： 2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)benzamide hydrochloride

纯度： ≥97% (HPLC)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for HJC 0416 hydrochloride

HJC 0416 hydrochloride is a STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC₅₀ values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.

化合物库 for HJC 0416 hydrochloride

HJC 0416 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for HJC 0416 hydrochloride

分子量	429.32
公式	C₁₈H₁₇ClN₂O₄S.HCl
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	2415263-08-8
InChI Key	YWFDTXJORDWLGD-UHFFFAOYSA-N
Smiles	ClC(C=C1)=CC(C(NC2=CC=C3C=CS(=O)(C3=C2)=O)=O)=C1OCCCN.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HJC 0416 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	42.93	100
	water	8.59	20

制备储备液 for HJC 0416 hydrochloride

以下数据基于产品分子量 429.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.33 mL	11.65 mL	23.29 mL
5 mM	0.47 mL	2.33 mL	4.66 mL
10 mM	0.23 mL	1.16 mL	2.33 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for HJC 0416 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for HJC 0416 hydrochloride

参考文献是支持产品生物活性的出版物。

Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID: 24904966

If you know of a relevant reference for HJC 0416 hydrochloride, please let us know.

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