Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewHS 38
说明： ATP-competitive inhibitor of DAPK and ZIPK
化学名： 2-[[1-(3-Chlorophenyl)-4,5-dihydro-4-oxo-1H-pyrazolo[3,4-d]pyrimidin-6-yl]thio]propanamide
纯度： ≥98% (HPLC)
生物活性 for HS 38
HS 38 is an ATP-competitive inhibitor of DAPK (IC50 = 200 nM) and ZIPK (Kd = 280 nM). Also inhibits PIM3 kinase (IC50 = 200 nM) but exhibits no significant effect on Src or Abl kinases. Reduces phosphorylation of regulatory myosin light chain and myosin light chain phosphatase in mouse aortic and rabbit ileal tissues.
技术数据 for HS 38
| 分子量 | 349.8 |
| 公式 | C14H12CIN5O2S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1030203-81-6 |
| PubChem ID | 42938883 |
| InChI Key | BDVPSWBRXLWRCV-UHFFFAOYSA-N |
| Smiles | O=C1NC(SC(C(N)=O)C)=NC2=C1C=NN2C3=CC=CC(Cl)=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HS 38
参考文献 for HS 38
参考文献是支持产品生物活性的出版物。
MacDonald et al (2016) A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol.Pharmacol. 89 105 PMID: 26464323
Carlson et al (2013) Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. ACS.Chem.Biol. 8 2715 PMID: 24070067
按标靶查看相关产品
按产品操作查看相关产品
关键词: HS 38, HS 38 supplier, HS38, ATP-competitive, inhibitors, inhibits, DAPK, ZIPK, PIM3, kinase, regulatory, myosin, light, chain, llight, phosphatase, 5768, Tocris Bioscience
HS 38 的评论
目前没有该产品的评论。 Be the first to review HS 38 and earn rewards!
Have you used HS 38?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image