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Hypericin

Cat. No. 1520 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1520 has been discontinued.

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说明： Inhibits tyrosine kinases
化学名： 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Hypericin

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC50 = 7.5 μM) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

技术数据 for Hypericin

分子量 504.45
公式 C30H16O8
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 548-04-9
PubChem ID 5281051
InChI Key BTXNYTINYBABQR-UHFFFAOYSA-N
Smiles OC1=C(C5=C(O)C=C(O)C4=C56)C(C(C(C(C7=C(C)C=C8O)=C(C)C=C3O)=C3C2=O)=C6C7=C8C4=O)=C2C(O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Hypericin

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for Hypericin

参考文献是支持产品生物活性的出版物。

Agostinis et al (2002) Hypericin in cancer treatment: more light on the way. Int.J.Biochem.Cell Biol. 34 221 PMID: 11849990

Hwang et al (2001) Inhibition of c-erbB-2 expression and activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 21 2649 PMID: 11724334

Lenard et al (1993) Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation. Proc.Natl.Acad.Sci.U.S.A. 90 158 PMID: 7678335

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关键词: Hypericin, Hypericin supplier, inhibitors, inhibits, tyrosine, kinases, Protein, Kinase, Broad, Spectrum, Inhibitors, Non-selective, Antivirals, 1520, Tocris Bioscience

1 篇 Hypericin 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Hypericin 的部分引用包括：

Chen et al (2018) Concomitant SK current activation and sodium current inhibition cause J wave syndrome. JCI Insight 3 PMID: 30429367

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