主页 / 药理学 / Enzymes / Kinases / Casein Kinase 1 / Casein Kinase 1 Inhibitors / IC 261

IC 261

Cat. No. 6676 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6676 has been discontinued.

View all Casein Kinase 1 products.
说明： CK1 inhibitor; displays selectivity for CK1δ and CK1ε
化学名： 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for IC 261

IC 261 is an ATP-competitive casein kinase 1 (CK1) inhibitor. Displays >15 fold selectivity for CK1δ and CK1ε over CK1α (IC50 values are approximately 1 μM for CK1δ and CK1ε and 16 μM for CK1α). Arrests cell cycle at postmitotic G1 phase in cells expressing p53. Inhibits CK1 mediated phosphorylation of LRRK2 in cell lines.

技术数据 for IC 261

分子量 311.33
公式 C18H17NO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 186611-52-9
PubChem ID 3674
InChI Key JBJYTZXCZDNOJW-UHFFFAOYSA-N
Smiles COC1=CC(OC)=C(C(OC)=C1)/C=C2C(NC3=C/2C=CC=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for IC 261

参考文献是支持产品生物活性的出版物。

Behrend et al (2000) IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 19 5303 PMID: 11103931

Mashhoon et al (2000) Crystal structure of a conformation-selective casein kinase-1 inhibitor. J.Med.Chem. 275 20052 PMID: 10749871

Chia et al (2014) Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat.Commun. 5 5827 PMID: 25500533

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Casein Kinase 1 Inhibitors

关键词: IC 261, IC 261 supplier, IC261, casein, kinase, 1, CK1, inhibitor, inhibits, CK1delta, CK1epsilon, Casein, Kinase, 6676, Tocris Bioscience

篇 IC 261 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 IC 261 的引用文献。

IC 261 的评论

目前没有该产品的评论。 Be the first to review IC 261 and earn rewards!

Have you used IC 261?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets