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iMDK

Cat. No. 5126 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Suppressor of MDK expression; inhibits PI 3-K signaling
化学名： 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for iMDK

iMDK is a suppressor of endogenous midkine (MDK) expression. Inhibits PI 3-K signaling in H441 lung adenocarcinoma cells. Selectively attenuates growth of MDK-expressing cancer cells. Induces apoptosis in H441 cells and suppresses growth of H441 cell xenografts in mice.

技术数据 for iMDK

分子量 376.4
公式 C21H13FN2O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 881970-80-5
PubChem ID 15991416
InChI Key IWFKQTWYILKFGE-UHFFFAOYSA-N
Smiles FC(C=C5)=CC=C5CC4=CN1C(S4)=NC(C(C(O3)=O)=CC2=C3C=CC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for iMDK

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 1.88 5

制备储备液 for iMDK

以下数据基于产品分子量 376.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 53.13 mL 265.67 mL 531.35 mL
0.25 mM 10.63 mL 53.13 mL 106.27 mL
0.5 mM 5.31 mL 26.57 mL 53.13 mL
2.5 mM 1.06 mL 5.31 mL 10.63 mL

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产品说明书 for iMDK

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for iMDK

参考文献是支持产品生物活性的出版物。

Hao et al (2013) Inhibition of the growth factor MDK/Midkine by a novel small molecule compound to treat non-small cell lung cancer. PLoS ONE 8 e71093 PMID: 23976985

If you know of a relevant reference for iMDK, please let us know.

按标靶查看相关产品

关键词: iMDK, iMDK supplier, iMDK, MDK, expression, lung, adenocarcinoma, KRAS, PI3, kinases, apoptosis, cancer, midkine, Cytokines, PI, 3-Kinase, 5126, Tocris Bioscience

1 篇 iMDK 的引用文献

引用文献是使用了 Tocris 产品的出版物。 iMDK 的部分引用包括：

Clara et al (2020) Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration. Elife 9 PMID: 31934849

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