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IND 1316

Cat. No. 7685 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： AMPK activator
化学名： 3-[3-(Phenylmethoxy)phenyl]-1H-indole-2-carboxylic acid
纯度： ≥98% (HPLC)
说明书
引用文献
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通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for IND 1316

IND 1316 is an activator of AMP-activated protein kinase (AMPK). In vitro, it activates AMPK in a dose-dependent manner and induces different MAPK pathways (p38 and JNK). In vivo, it reduces the neuropathological symptoms in two animal models of Huntington's Disease (nematodes and mice). It shows very low toxicity even at high concentrations (>200 μM). This compound is orally bioavailable.

技术数据 for IND 1316

分子量 343.38
公式 C22H17NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1888473-12-8
PubChem ID 130234214
InChI Key WFARYZNGGCHILS-UHFFFAOYSA-N
Smiles OC(C1=C(C2=CC(OCC3=CC=CC=C3)=CC=C2)C4=CC=CC=C4N1)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for IND 1316

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 34.34 100
ethanol 34.34 100

制备储备液 for IND 1316

以下数据基于产品分子量 343.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.91 mL 14.56 mL 29.12 mL
5 mM 0.58 mL 2.91 mL 5.82 mL
10 mM 0.29 mL 1.46 mL 2.91 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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参考文献 for IND 1316

参考文献是支持产品生物活性的出版物。

Vela et al (2022) Neuroprotective effect of IND1316, an indole-based AMPK activator, in animal models of Huntington disease. ACS Chem.Neurosci. 13 275 PMID: 34962383

If you know of a relevant reference for IND 1316, please let us know.

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关键词: IND 1316, IND 1316 supplier, IND1316, AMPK, activators, AMP-Activated, Protein, Kinases, Enzyme, Substrates, orally, bioavailable, huntingtons, /, Activators, 7685, Tocris Bioscience

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Pathways for IND 1316

AMPK Signaling Pathway

AMPK Signaling Pathway

AMPK signaling pathway plays an important role in the cellular reponse to low levels of available ATP, often caused by stresses such as heat shock, ischemia or hypoxia.