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J 147

Cat. No. 5081 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels
化学名： 2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for J 147

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

许可信息

Sold for research use only under license from the Salk Institute for Biological Studies

化合物库 for J 147

J 147 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for J 147

分子量 350.33
公式 C18H17F3N2O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1146963-51-0
PubChem ID 25229652
InChI Key HYMZAYGFKNNHDN-SSDVNMTOSA-N
Smiles O=C(C(F)(F)F)N(C2=C(C)C=C(C)C=C2)/N=C/C1=CC=CC(OC)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for J 147

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.03 100
ethanol 35.03 100

制备储备液 for J 147

以下数据基于产品分子量 350.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.54 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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参考文献 for J 147

参考文献是支持产品生物活性的出版物。

Chen et al (2011) A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease. PLoS One 6 e27865 PMID: 22194796

Prior et al (2013) The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice. Alzheimer's.Res.Ther. 5 25 PMID: 23673233

Chiruta et al (2013) Metabolism of a potent neuroprotective hydrazide. Bioorg.Med.Chem. 21 2733 PMID: 23582448

If you know of a relevant reference for J 147, please let us know.

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关键词: J 147, J 147 supplier, neuroprotective, neurotrophic, J147, Alzheimers, disease, AD, amyloidbeta, amyloidb, amyloidβ, Amyloid, Beta, Peptides, 5081, Tocris Bioscience

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