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Submit ReviewJH 295
说明： Irreversible Nek2 inhibitor
化学名： N-[(3Z)-3-[(2-Ethyl-4-methyl-1H-imidazol-5-yl)methylene]-2,3-dihydro-2-oxo-1H-indol-5-yl]-2-propynamide
纯度： ≥98% (HPLC)
生物活性 for JH 295
JH 295 is an irreversible Nek2 inhibitor (IC50=770 nM). Inhibits Nek2 via alkylation of residue Cys22. Displays 5-fold selectivity for Nek2 over Cdk1. Exhibits no significant effect on Aurora B or Plk1 kinases, bipolar spindle assembly or spindle assembly checkpoint. Cell permeable.
技术数据 for JH 295
| 分子量 | 320.35 |
| 公式 | C18H16N4O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1311143-71-1 |
| PubChem ID | 53262909 |
| InChI Key | ORKOHXAJFGRZCL-LCYFTJDESA-N |
| Smiles | O=C2NC1=CC=C(NC(C#C)=O)C=C1/C2=C/C3=C(C)N=C(CC)N3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JH 295
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.03 | 100 |
制备储备液 for JH 295
以下数据基于产品分子量 320.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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产品说明书 for JH 295
参考文献 for JH 295
参考文献是支持产品生物活性的出版物。
Henise et al (2011) Irreversible Nek2 kinase inhibitors with cellular activity. J.Med.Chem. 54 4133 PMID: 21627121
If you know of a relevant reference for JH 295, please let us know.
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关键词: JH 295, JH 295 supplier, JH295, Nek2, inhibitor, inhibits, irreversible, alkylation, Kinase, 4322, Tocris Bioscience
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