JNJ 10198409

Cat. No. 6976 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent PDGFRα and PDGFRβ inhibitor; also inhibits c-Abl, Lck, c-Src and Fyn kinases

化学名： N-(3-Fluorophenyl)-1,4-dihydro-6,7-dimethoxyindeno[1,2-c]pyrazol-3-amine

纯度： ≥98% (HPLC)

引用文献 (8)

实验方案 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for JNJ 10198409

JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC₅₀ values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC₅₀ values are 22, 100, 185 and 378 nM respectively). Displays antiproliferative activity in multiple tumor cell lines. Accelerates down regulation of fibroblast genes in transdifferentiation of human fibroblasts into functional cardiomyocytes, within 9C cocktail.

For more information about how JNJ 10198409 may be used, see our protocol: Converting Fibroblasts into Cardiomyocytes (9C Cocktail)

许可信息

Sold with the permission of Janssen Pharmaceutica N.V.

化合物库 for JNJ 10198409

JNJ 10198409 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library, Tocriscreen Antiviral Library and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。

技术数据 for JNJ 10198409

分子量	325.34
公式	C₁₈H₁₆FN₃O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	627518-40-5
PubChem ID	9797370
InChI Key	ZDNURMVOKAERHZ-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C2C(CC3=C2NN=C3NC2=CC(F)=CC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JNJ 10198409

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	6.51	20
	ethanol	32.53	100

制备储备液 for JNJ 10198409

以下数据基于产品分子量 325.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.07 mL	15.37 mL	30.74 mL
5 mM	0.61 mL	3.07 mL	6.15 mL
10 mM	0.31 mL	1.54 mL	3.07 mL
50 mM	0.06 mL	0.31 mL	0.61 mL

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产品说明书 for JNJ 10198409

分析证书/产品说明书

化学品安全技术说明书

参考文献 for JNJ 10198409

参考文献是支持产品生物活性的出版物。

Ho et al (2005) (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J.Med.Chem. 29 8163 PMID: 16366598

Cao et al (2016) Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 352 1216 PMID: 27127239

If you know of a relevant reference for JNJ 10198409, please let us know.

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