Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewJP-2-196 alkyne 最新
说明： RNF126 chemical handle; alkyne functionalized version of JP-2-196 (Cat. No. 8046).
化学名： 1-(4-Methoxyphenyl)-4-[4-(2-propyn-1-yl)-1-piperazinyl]-2-butene-1,4-dione
纯度： ≥95% (HPLC)
生物活性 for JP-2-196 alkyne
JP-2-196 alkyne is a covalent RNF126 chemical handle that binds to several other RING E3 ubiquitin ligases including RNF14, RNF40, RNF219, MID2, and LRSAM1. By facilitating E3 ligase recruitment, JP-2-196 alkyne induces proteasomal degradation of diverse target proteins. It serves as a modular scaffold for the design and synthesis of molecular glue degraders. JP-2-196 alkyne is an alkyne functionalized version of JP-2-196 (Cat. No. 8046).
技术数据 for JP-2-196 alkyne
| 分子量 | 312.37 |
| 公式 | C18H20N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2901113-25-3 |
| PubChem ID | 167740300 |
| InChI Key | COPXSSDNGLPYDY-CMDGGOBGSA-N |
| Smiles | O=C(C1=CC=C(C=C1)OC)/C=C/C(N2CCN(CC2)CC#C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for JP-2-196 alkyne
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 31.24 | 100 |
制备储备液 for JP-2-196 alkyne
以下数据基于产品分子量 312.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.2 mL | 16.01 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.2 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for JP-2-196 alkyne
参考文献 for JP-2-196 alkyne
参考文献是支持产品生物活性的出版物。
Toriki et al (2023) Rational chemical design of molecular glue Degraders. ACS Cent.Sci. 9 915 PMID: 37252349
If you know of a relevant reference for JP-2-196 alkyne, please let us know.
按标靶查看相关产品
关键词: JP-2-196 alkyne, JP-2-196 alkyne supplier, JP2-196, alkyne, e3, ligase, RNF126, ligands, targeted, protein, TPD, Degrader, Degraders, molecular, glue, Ubiquitin, E3, Ligases, Molecular, Glues, 8047, Tocris Bioscience
篇 JP-2-196 alkyne 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 JP-2-196 alkyne 的引用文献。 您是否知道使用了 Tocris JP-2-196 alkyne 的优秀论文？ 请告知我们.
JP-2-196 alkyne 的评论
目前没有该产品的评论。 Be the first to review JP-2-196 alkyne and earn rewards!
Have you used JP-2-196 alkyne?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia