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K-252c

Cat. No. 2287 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2287 has been discontinued.

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说明： Protein kinase C inhibitor
别名： Staurosporinone
化学名： 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for K-252c

K-252c is an inhibitor of protein kinase C (IC50 = 2.45 μM) that displays ~ 10-fold selectivity over protein kinase A (IC50 = 25.7 μM). Also inhibits β-lactamase, malate dehydrogenase and chymotrypsin (IC50 values are 8, 8 and 10 μM respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC50 values range from 0.13 - 0.32 μM). Shows no activity against herpes simplex virus (HSV).

技术数据 for K-252c

分子量 311.34
公式 C20H13N3O
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 85753-43-1
PubChem ID 3815
InChI Key MEXUTNIFSHFQRG-UHFFFAOYSA-N
Smiles O=C(NC3)C1=C3C(C4=CC=CC=C4N5)=C5C2=C1C6=C(C=CC=C6)N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for K-252c

参考文献是支持产品生物活性的出版物。

Fabre et al (1993) Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg.Med.Chem. 1 193 PMID: 8081852

Zimmermann et al (2000) Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase. Antiviral Res. 48 49 PMID: 11080540

McGovern and Shoichet (2003) Kinase inhibitors: not just for kinases anymore. J.Med.Chem. 46 1478 PMID: 12672248

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关键词: K-252c, K-252c supplier, Protein, kinases, C, inhibitors, inhibits, PKC, Staurosporinone, Kinase, Cytomegalovirus, 2287, Tocris Bioscience

1 篇 K-252c 的引用文献

引用文献是使用了 Tocris 产品的出版物。 K-252c 的部分引用包括：

Goldman et al (2012) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol 19 855 PMID: 22840773

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