Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit Reviewkb NB 142-70
说明： Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
化学名： 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
纯度： ≥98% (HPLC)
生物活性 for kb NB 142-70
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
技术数据 for kb NB 142-70
| 分子量 | 251.32 |
| 公式 | C11H9NO2S2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1233533-04-4 |
| PubChem ID | 45258277 |
| InChI Key | DHUAGGSHTKPOHU-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(SC3=C2SCCNC3=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for kb NB 142-70
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.13 | 100 |
制备储备液 for kb NB 142-70
以下数据基于产品分子量 251.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.89 mL | 39.79 mL |
| 5 mM | 0.8 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.4 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for kb NB 142-70
参考文献 for kb NB 142-70
参考文献是支持产品生物活性的出版物。
LaValle et al (2010) Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 10 5 PMID: 20444281
Bravo-Altamirano et al (2011) Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2 154 PMID: 21617763
Ni et al (2013) PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 8 e73149 PMID: 24039875
If you know of a relevant reference for kb NB 142-70, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: kb NB 142-70, kb NB 142-70 supplier, PKD, protein, kinase, D, inhibitor, analog, selective, inhibitors, inhibits, analogs, kbNB142-70, Protein, Kinase, 3962, Tocris Bioscience
4 篇 kb NB 142-70 的引用文献
引用文献是使用了 Tocris 产品的出版物。 kb NB 142-70 的部分引用包括：
Zhang et al (2017) Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med 214 2671 PMID: 28716882
Weber et al (2015) A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol 9 9 PMID: 25889812
Xiong et al (2016) Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep 6 34079 PMID: 27659202
Stephan A et al (2021) Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic 22 454-470 PMID: 34564930
您是否知道使用了 Tocris kb NB 142-70 的优秀论文？ 请告知我们.
kb NB 142-70 的评论
目前没有该产品的评论。 Be the first to review kb NB 142-70 and earn rewards!
Have you used kb NB 142-70?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image