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说明： Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327)
化学名： 9-Hydroxy-3,4-dihydro-2H-[1]-benzothiolo[2,3-f][1,4]thiazepin-5-one
纯度： ≥98% (HPLC)
生物活性 for kb NB 142-70
kb NB 142-70 is a selective protein kinase D (PKD) inhibitor (IC50 values are 28.3, 58.7 and 53.2 nM for PKD1, 2 and 3 respectively). More potent analog of CID 755673 (Cat. No. 3327) with 7-fold greater inhibition. Inhibits prostrate cancer cell migration and invasion and reduces wound healing in vitro; displays prominent cytotoxic and anti-proliferative effects.
技术数据 for kb NB 142-70
| 分子量 | 251.32 |
| 公式 | C11H9NO2S2 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1233533-04-4 |
| PubChem ID | 45258277 |
| InChI Key | DHUAGGSHTKPOHU-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(SC3=C2SCCNC3=O)C2=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for kb NB 142-70
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 25.13 | 100 |
制备储备液 for kb NB 142-70
以下数据基于产品分子量 251.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.98 mL | 19.89 mL | 39.79 mL |
| 5 mM | 0.8 mL | 3.98 mL | 7.96 mL |
| 10 mM | 0.4 mL | 1.99 mL | 3.98 mL |
| 50 mM | 0.08 mL | 0.4 mL | 0.8 mL |
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产品说明书 for kb NB 142-70
参考文献 for kb NB 142-70
参考文献是支持产品生物活性的出版物。
LaValle et al (2010) Novel protein kinase D inhibitors cause potent arrest in cancer cell growth and motility. BMC Chemical Biology 10 5 PMID: 20444281
Bravo-Altamirano et al (2011) Synthesis and structure-activity relationships of benzothienothiazepinone inhibitors of protein kinase D. ACS Med.Chem.Lett. 2 154 PMID: 21617763
Ni et al (2013) PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One 8 e73149 PMID: 24039875
If you know of a relevant reference for kb NB 142-70, please let us know.
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关键词: kb NB 142-70, kb NB 142-70 supplier, PKD, protein, kinase, D, inhibitor, analog, selective, inhibitors, inhibits, analogs, kbNB142-70, Protein, Kinase, 3962, Tocris Bioscience
4 篇 kb NB 142-70 的引用文献
引用文献是使用了 Tocris 产品的出版物。 kb NB 142-70 的部分引用包括：
Stephan A et al (2021) Protein kinase D promotes activity-dependent AMPA receptor endocytosis in hippocampal neurons. Traffic 22 454-470 PMID: 34564930
Weber et al (2015) A computational model of PKD and CERT interactions at the trans-Golgi network of mammalian cells. BMC Syst Biol 9 9 PMID: 25889812
Xiong et al (2016) Protein Kinase D2 Protects against Acute Colitis Induced by Dextran Sulfate Sodium in Mice. Sci Rep 6 34079 PMID: 27659202
Zhang et al (2017) Protein kinase D at the Golgi controls NLRP3 inflammasome activation. J Exp Med 214 2671 PMID: 28716882
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