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Kobe 0065

Cat. No. 5475 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5475 has been discontinued.

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说明： H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling
化学名： N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
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生物活性 技术数据 说明书 参考文献

生物活性 for Kobe 0065

H-Ras-cRaf1 interaction inhibitor; inhibits Raf signaling. Selectively attenuates proliferation and induces apoptosis of cancer cells harboring Ras oncogenes. Reduces growth of K-Ras mutant SW480 colon carcinoma cell xenografts in mice. Orally active.

技术数据 for Kobe 0065

分子量 449.79
公式 C15H11ClF3N5O4S
储存 Store at +4°C
CAS Number 436133-68-5
PubChem ID 3827663
InChI Key KSJVAYBCXSURMQ-UHFFFAOYSA-N
Smiles CC1=C(Cl)C=C(NC(NNC2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2[N+]([O-])=O)=S)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Kobe 0065

参考文献是支持产品生物活性的出版物。

Shima et al (2013) In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.U.S.A. 110 8182 PMID: 23630290

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关键词: Kobe 0065, Kobe 0065 supplier, Kobe0065, H-ras-GTP, cRaf, interaction, inhibitors, inhibits, orally, active, Raf, Kinase, 5475, Tocris Bioscience

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