Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewKT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
分子量 | 495.53 |
公式 | C29H25N3O5 |
储存 | Desiccate at -20°C |
纯度 | ≥95% (HPLC) |
CAS Number | 126643-37-6 |
PubChem ID | 108152 |
InChI Key | QTYMDECKVKSGSM-YMUMJAELSA-N |
Smiles | [H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 24.78 | 50 |
以下数据基于产品分子量 495.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 4.04 mL | 20.18 mL | 40.36 mL |
2.5 mM | 0.81 mL | 4.04 mL | 8.07 mL |
5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
25 mM | 0.08 mL | 0.4 mL | 0.81 mL |
参考文献是支持产品生物活性的出版物。
Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626 PMID: 1528872
Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171 PMID: 7840145
Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 358 134 PMID: 9721015
If you know of a relevant reference for KT 5823, please let us know.
关键词: KT 5823, KT 5823 supplier, Selective, protein, kinases, G, inhibitors, inhibits, PKG, cGMP, KT5823, Protein, Kinase, 1289, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 KT 5823 的部分引用包括:
Kuo et al (2014) A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci 10 64 PMID: 24391452
Jayabal et al (2023) Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma Cell Rep 42 112103 PMID: 36773293
Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335 PMID: 24353062
Giricz et al (2009) Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. J Neurosci 158 1495 PMID: 19845676
Pulkkinen et al (2012) The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol 303 L956 PMID: 22962016
Livingstone et al (2019) Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci 12 198 PMID: 31474829
您是否知道使用了 Tocris KT 5823 的优秀论文? 请告知我们.
目前没有该产品的评论。 Be the first to review KT 5823 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image