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说明： Selective protein kinase G inhibitor
化学名： (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester
纯度： ≥95% (HPLC)
生物活性 for KT 5823
KT 5823 is a selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
技术数据 for KT 5823
| 分子量 | 495.53 |
| 公式 | C29H25N3O5 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 126643-37-6 |
| PubChem ID | 108152 |
| InChI Key | QTYMDECKVKSGSM-YMUMJAELSA-N |
| Smiles | [H][C@]18O[C@](N6C4=C3N1C2=CC=CC=C2C3=C7C(CN(C7=O)C)=C4C5=CC=CC=C56)([C@]([C@@](OC)=O)(OC)C8)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for KT 5823
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 24.78 | 50 |
制备储备液 for KT 5823
以下数据基于产品分子量 495.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.04 mL | 20.18 mL | 40.36 mL |
| 2.5 mM | 0.81 mL | 4.04 mL | 8.07 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
| 25 mM | 0.08 mL | 0.4 mL | 0.81 mL |
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产品说明书 for KT 5823
参考文献 for KT 5823
参考文献是支持产品生物活性的出版物。
Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626 PMID: 1528872
Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171 PMID: 7840145
Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 358 134 PMID: 9721015
If you know of a relevant reference for KT 5823, please let us know.
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关键词: KT 5823, KT 5823 supplier, Selective, protein, kinases, G, inhibitors, inhibits, PKG, cGMP, KT5823, Protein, Kinase, 1289, Tocris Bioscience
6 篇 KT 5823 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KT 5823 的部分引用包括：
Jayabal et al (2023) Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma Cell Rep 42 112103 PMID: 36773293
Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335 PMID: 24353062
Giricz et al (2009) Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. J Neurosci 158 1495 PMID: 19845676
Pulkkinen et al (2012) The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol 303 L956 PMID: 22962016
Livingstone et al (2019) Secreted Amyloid Precursor Protein-Alpha Promotes Arc Protein Synthesis in Hippocampal Neurons. Front Mol Neurosci 12 198 PMID: 31474829
Kuo et al (2014) A xanthine-derivative K(+)-channel opener protects against serotonin-induced cardiomyocyte hypertrophy via the modulation of protein kinases. Int J Biol Sci 10 64 PMID: 24391452
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