Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewKU 60019
Discontinued Product
This product has been withdrawn from sale and is superseded by KU 55933 (Cat. No. 3544)
说明： Potent ATM kinase inhibitor
化学名： (2R,6S-rel)-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl-4-morpholineacetamide
纯度： ≥98% (HPLC)
生物活性 for KU 60019
Potent ATM kinase inhibitor (IC50 = 6.3 nM). Exhibits little to no nonspecific target effects against a panel of 229 protein kinases; displays similar target selectivity to KU 55933 (Cat. No. 3544). Inhibits migration and invasion of human glioma cells in vitro.
许可信息
Sold with the permission of AstraZeneca.
External Portal Information for KU 60019
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of KU 60019 is reviewed on the chemical probes website.
技术数据 for KU 60019
| 分子量 | 547.67 |
| 公式 | C30H33N3O5S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 925701-46-8 |
| PubChem ID | 15953870 |
| InChI Key | SCELLOWTHJGVIC-BGYRXZFFSA-N |
| Smiles | O=C(CN4C[C@H](C)O[C@H](C)C4)NC(C=C3)=CC2=C3SC1=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C1C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for KU 60019
参考文献 for KU 60019
参考文献是支持产品生物活性的出版物。
Golding et al (2009) Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises Ins, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol.Cancer Ther. 8 2894 PMID: 19808981
按产品操作查看相关产品
关键词: KU 60019, KU 60019 supplier, Astrazeneca, KU60019, atm, kinases, ataxia, telangiectasia, mutated, potent, inhibitors, inhibits, ATM, &, ATR, Kinase, Checkpoint, Control, Kinases, 4176, Tocris Bioscience
14 篇 KU 60019 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KU 60019 的部分引用包括：
Wu et al (2014) Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem 289 34378 PMID: 25336634
Deng et al (2016) Replication of an Autonomous Human Parvovirus in Non-dividing Human Airway Epithelium Is Facilitated through the DNA Damage and Repair Pathways. PLoS Pathog 12 e1005399 PMID: 26765330
Müllers et al (2014) Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase. Cell Cycle 13 2733 PMID: 25486360
Ryl et al (2017) Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug. Cell Syst 5 237 PMID: 28843484
Jaiswal et al (2017) ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration. EMBO J 36 2161 PMID: 28607002
Rass et al (2013) Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. J Biol Chem 288 7086 PMID: 23355489
Yang et al (2018) Cell type-dependent bimodal p53 activation engenders a dynamic mechanism of chemoresistance. Sci Adv 4 eaat5077 PMID: 30585287
Koo et al (2015) RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. Nucleic Acids Res 290 7463 PMID: 25623070
Parplys et al (2015) NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Cell Cycle 43 9817 PMID: 26323318
Davari et al (2014) Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle 13 3659 PMID: 25483076
Barton et al (2014) Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol 206 877 PMID: 25267294
Mehta et al (2015) Human papillomaviruses activate and recruit SMC1 cohesin proteins for the differentiation-dependent life cycle through association with CTCF insulators. PLoS Pathog 11 e1004763 PMID: 25875106
Montané and Menand (2013) ATP-competitive mTOR kinase inhibitors delay plant growth by triggering early differentiation of meristematic cells but no developmental patterning change. J Biol Chem 64 4361 PMID: 23963679
Gautam (2013) The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication. J Virol 87 8687 PMID: 23740981
KU 60019 的评论
目前没有该产品的评论。 Be the first to review KU 60019 and earn rewards!
Have you used KU 60019?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.