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L-779,450

Cat. No. 3185 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3185 has been discontinued.

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说明： Potent Raf kinase inhibitor
化学名： 2-Chloro-5-[2-Phenyl-5-(4-pyridinyl)-1H-imidazol-4-yl]phenol
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for L-779,450

Potent, ATP-competitive Raf kinase inhibitor (IC50 = 10 nM) that displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively. Suppresses DNA synthesis and induces apoptosis in cells that proliferate in response to Raf-1 and A-Raf but not B-Raf.

技术数据 for L-779,450

分子量 347.8
公式 C20H14ClN3O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 303727-31-3
PubChem ID 9950176
Smiles ClC(C(O)=C4)=CC=C4C(N=C(C3=CC=CC=C3)N2)=C2C1=CC=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for L-779,450

参考文献是支持产品生物活性的出版物。

White (2003) Small-molecule inhibitors of signal transduction pathways in leukemia therapeutics: how to assess selectivity for malignant signals. Leukemia 17 1759 PMID: 12970775

Shelton et al (2003) Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia 17 1765 PMID: 12970777

Takle et al (2006) Identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg.Med.Chem.Letts. 16 378

Röring et al (2012) Distinct requirement for an intact dimer interface in wild-type, V600E and kinase-dead B-Raf signalling. EMBO J. 31 2629 PMID: 22510884

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关键词: L-779,450, L-779,450 supplier, Potent, raf, kinases, inhibitors, inhibits, a-raf, raf-1, L779450, Raf, Kinase, 3185, Tocris Bioscience

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