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LH 846

Cat. No. 4896 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4896 has been discontinued.

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说明： Selective casein kinase 1δ inhibitor
化学名： N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for LH 846

LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α); displays no inhibitory activity at CK2. Inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.

技术数据 for LH 846

分子量 316.81
公式 C16H13ClN2OS
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 639052-78-1
PubChem ID 851474
InChI Key DYHAMRNAHTWYKY-UHFFFAOYSA-N
Smiles O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for LH 846

参考文献是支持产品生物活性的出版物。

Lee et al (2011) A small molecule modulates circadian rhythms through phosphorylation of the period protein. Agnew Chem.Int.Ed.Engl. 50 10608 PMID: 21954091

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关键词: LH 846, LH 846 supplier, LH846, casein, kinase, I, CK1, CK1d, CK1delta, CK1δ, selective, inhibitors, inhibits, circadian, rhythm, clock, Casein, Kinase, 1, 4896, Tocris Bioscience

3 篇 LH 846 的引用文献

引用文献是使用了 Tocris 产品的出版物。 LH 846 的部分引用包括：

Causton et al (2015) Metabolic cycles in yeast share features conserved among circadian rhythms. Curr.Biol. 25 1056 PMID: 25866393

Zemp et al (2014) CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation. J Cell Sci 127 1242 PMID: 24424021

Greer et al (2017) Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PLoS One 12 e0170903 PMID: 28125685

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Cell Cycle and DNA Damage Research Product Guide

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