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Lopinavir

Cat. No. 7052 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent and selective HIV-1 protease inhibitor
别名： ABT-378
化学名： (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Lopinavir

Lopinavir is a highly potent and selective HIV-1 protease inhibitor (IC50 = 6.5 nM, HIV cultured in peripheral blood mononuclear cells; Ki = 1.3 pM). Displays >105-fold selectivity for HIV-1 protease over mammalian proteases including renin and cathepsin D and E. Inhibits HIV-1 protease in patient HIV isolates displaying mutations that confer resistance to ritonavir (Cat. No. 5856) (IC50 values in 5 - 50 nM range). Also inhibits SARS-CoV-2 replication in vitro (IC50 = 26 μM)

化合物库 for Lopinavir

Lopinavir is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Lopinavir

分子量 628.8
公式 C37H48N4O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 192725-17-0
PubChem ID 92727
InChI Key KJHKTHWMRKYKJE-SUGCFTRWSA-N
Smiles CC([C@@H](C(N[C@@H](CC1=CC=CC=C1)C[C@@H]([C@@H](NC(COC2=C(C=CC=C2C)C)=O)CC3=CC=CC=C3)O)=O)N4CCCNC4=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Lopinavir

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 62.88 100
ethanol 62.88 100

制备储备液 for Lopinavir

以下数据基于产品分子量 628.8。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.8 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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参考文献 for Lopinavir

参考文献是支持产品生物活性的出版物。

Sham et al (1998) ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob.Agents Chemother. 42 3218 PMID: 9835517

Carrillo et al (1998) In vitro selection and characterization of human immunodeficiency virus type 1 variants with increased resistance to ABT-378, a novel protease inhibitor. J.Virol. 72 7532 PMID: 9696850

Choy et al (2020) Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro. Antiviral Res. 178 PMID: 32251767

If you know of a relevant reference for Lopinavir, please let us know.

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