LY 2886721 Hydrochloride

Cat. No. 7081 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective β-secretase (BACE) inhibitor

化学名： N-[3-[(4aS,7aS)-2-Amino-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl]-4-fluorophenyl]-5-fluoro-2-pyridinecarboxamide hydrochloride

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for LY 2886721 Hydrochloride

LY 2886721 Hydrochloride is a potent and selective β-secretase (BACE) inhibitor (IC₅₀ values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin and renin. Inhibits Aβ1-40 and Aβ1-42 production in cells expressing mutated APP. Reduces hippocampal and cortical Aβ and sAPPβ levels in an Alzheimer's disease mouse model.

化合物库 for LY 2886721 Hydrochloride

LY 2886721 Hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LY 2886721 Hydrochloride

分子量	426.87
公式	C₁₈H₁₆F₂N₄O₂S.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1262036-49-6
PubChem ID	50902942
InChI Key	JHHMCINLHBUFHB-GHDSXOKHSA-N
Smiles	[H][C@@]12COC[C@]1(C3=CC(NC(C4=CC=C(C=N4)F)=O)=CC=C3F)N=C(SC2)N.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 2886721 Hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	42.69	100

制备储备液 for LY 2886721 Hydrochloride

以下数据基于产品分子量 426.87。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.34 mL	11.71 mL	23.43 mL
5 mM	0.47 mL	2.34 mL	4.69 mL
10 mM	0.23 mL	1.17 mL	2.34 mL
50 mM	0.05 mL	0.23 mL	0.47 mL

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产品说明书 for LY 2886721 Hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for LY 2886721 Hydrochloride

参考文献是支持产品生物活性的出版物。

May et al (2015) The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs and humans. J.Neurosci. 35 1199 PMID: 25609634

If you know of a relevant reference for LY 2886721 Hydrochloride, please let us know.

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