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LY 450139

Cat. No. 6559 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： γ-secretase pseudo-inhibitor
化学名： (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for LY 450139

LY 450139 is a γ-secretase pseudo-inhibitor. Inhibits Aβ secretion from cells in vitro and increases accumulation of γ-secretase products and long Aβ species in vitro and in vivo. Also attenuates the accumulation of activated microglia and neurological injury in a traumatic brain injury animal model.

化合物库 for LY 450139

LY 450139 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for LY 450139

分子量 361.44
公式 C19H27N3O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 425386-60-3
PubChem ID 9843750
InChI Key PKXWXXPNHIWQHW-RCBQFDQVSA-N
Smiles CC([C@@H](C(N[C@H](C(N[C@H]1C2=CC=CC=C2CCN(C1=O)C)=O)C)=O)O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for LY 450139

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.14 100
ethanol 18.07 50

制备储备液 for LY 450139

以下数据基于产品分子量 361.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.83 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for LY 450139

参考文献是支持产品生物活性的出版物。

Henley et al (2009) Development of semagacestat (LY450139), a functional gamma-secretase inhibitor, for the treatment of Alzheimer's disease. Expert Opin.Pharmacother. 10 1657 PMID: 19527190

Lanz et al (2006) Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139. J.Pharmacol.Exp.Ther. 319 924 PMID: 16920992

Tagami et al (2017) Semagacestat is a pseudo-inhibitor of γ-secretase. Cell Rep. 21 259 PMID: 28978478

Lin et al (2017) Gamma-secretase inhibitors attenuate neurotrauma and neurogenic acute lung injury in rats by rescuing the accumulation of hypertrophic microglia. Cell Physiol.Biochem. 44 1726 PMID: 29227981

If you know of a relevant reference for LY 450139, please let us know.

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关键词: LY 450139, LY 450139 supplier, LY450139, Semagacestat, gamma, secretase, inhibitor, inhibits, amyloid, beta, secretion, Abeta, Gamma-Secretase, 6559, Tocris Bioscience

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