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Mandi

Cat. No. 7681 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Highly efficient chemical inducer of proximity (CIP)
化学名： 4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mandi

Mandi is a chemical inducer of proximity (CIP) in vivo and in vitro (EC50 = 0.43 μM in a luciferase gene expression assay). Mandi induces complex formation between PYR1Mandi, a mutant of Abscisic Acid (Cat. No. 6554) receptor PYR1, and Abscisic Acid insensitive (ABI). Mandi may be used to induce protein colocalization and interaction. It is non-toxic, orthogonal to mammalian processes and other CIPs, and highly cell permeable.

技术数据 for Mandi

分子量 411.88
公式 C23H22ClNO4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 374726-62-2
PubChem ID 11292824
InChI Key KWLVWJPJKJMCSH-UHFFFAOYSA-N
Smiles C#CCOC(C=CC(CCNC(C(C1=CC=C(C=C1)Cl)OCC#C)=O)=C2)=C2OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mandi

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.19 100

制备储备液 for Mandi

以下数据基于产品分子量 411.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.14 mL 24.28 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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参考文献 for Mandi

参考文献是支持产品生物活性的出版物。

Ziegler et al (2022) Mandipropamid as a chemical inducer of proximity for in vivo applications. Nat.Chem.Biol. 18 64 PMID: 34934192

Park et al (2023) An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity. Nat.Chem.Biol. PMID: 37872402

If you know of a relevant reference for Mandi, please let us know.

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关键词: Mandi, Mandi supplier, chemical, inducer, of, proximity, CIP, CIPs, mutant, pyrabactin, resistance, 1, PYR1, abscisic, acid, insensitive, ABI, induce, protein, colocalization, in, vitro, vivo, Protein, Dimerizers, 7681, Tocris Bioscience

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