MeBIO

Cat. No. 3873 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Inactive analog of BIO (Cat. No. 3194)

化学名： (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime

纯度： ≥99% (HPLC)

说明书

引用文献 (2)

文献 (4)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MeBIO

MeBIO is a control analog of 6-bromoindirubin-3'-oxime (BIO). Displays minimal activity against CDK1/Cyclin B, GSK-3 α/β, and CDK5/p25 (IC₅₀ values are 92.0, 44-100 and >100 μM respectively). Aryl hydrocarbon receptor (AhR) agonist; causes redistribution of AhR to the nucleus.

Active Analog also available.

技术数据 for MeBIO

分子量	370.2
公式	C₁₇H₁₂BrN₃O₂
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	667463-95-8
PubChem ID	24906281
InChI Key	WWVVQXIBSZPELF-UHFFFAOYSA-N
Smiles	O/N=C(C1=CC=CC=C1N2)/C2=C3/C(N(C)C4=C3C=CC(Br)=C4)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MeBIO

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	3.7	10

制备储备液 for MeBIO

以下数据基于产品分子量 370.2。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.1 mM	27.01 mL	135.06 mL	270.12 mL
0.5 mM	5.4 mL	27.01 mL	54.02 mL
1 mM	2.7 mL	13.51 mL	27.01 mL
5 mM	0.54 mL	2.7 mL	5.4 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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产品说明书 for MeBIO

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MeBIO

参考文献是支持产品生物活性的出版物。

Knockaert et al (2004) Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene 23 4400 PMID: 15077192

Meijer et al (2003) GSK-3-selective inhibitors derived from tyrian purple indirubins. Chem.Biol. 10 1255 PMID: 14700633

Polychronopoulos et al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935 PMID: 14761195

If you know of a relevant reference for MeBIO, please let us know.

按标靶查看相关产品

关键词: MeBIO, MeBIO supplier, GSK-3, inhibitors, inhibits, control, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, stem, cells, aryl, hydrocarbon, receptor, Kinase, Aryl, Hydrocarbon, Receptors, 3873, Tocris Bioscience

2 篇 MeBIO 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MeBIO 的部分引用包括：

Volpini et al (2018) Trypanosoma cruzi Exploits Wnt Signaling Pathway to Promote Its Intracellular Replication in Macrophages. Front Immunol 9 859 PMID: 29743880

Diamantopoulou et al (2017) TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells. Cancer Cell 31 621 PMID: 28416184

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for MeBIO

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.