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Submit Review(-)-JQ1
说明： Negative control for (+)-JQ1
化学名： (6R)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
纯度： ≥98% (HPLC)
生物活性 for (-)-JQ1
(-)-JQ1 is an inactive control for (+)-JQ1. Exhibits no significant interaction with BRD1-4 or a panel of other bromodomains.
Active Enantiomer also available.
许可信息
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the (+)-JQ1 probe summary on the SGC website.
化合物库 for (-)-JQ1
(-)-JQ1 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for (-)-JQ1
| 分子量 | 456.99 |
| 公式 | C23H25ClN4O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1268524-71-5 |
| PubChem ID | 49871818 |
| InChI Key | DNVXATUJJDPFDM-QGZVFWFLSA-N |
| Smiles | O=C(OC(C)(C)C)C[C@H]1N=C(C4=CC=C(Cl)C=C4)C3=C(SC(C)=C3C)N2C1=NN=C2C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for (-)-JQ1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 45.7 | 100 | |
| ethanol | 45.7 | 100 |
制备储备液 for (-)-JQ1
以下数据基于产品分子量 456.99。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.94 mL | 21.88 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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产品说明书 for (-)-JQ1
参考文献 for (-)-JQ1
参考文献是支持产品生物活性的出版物。
Filippakopoulos et al (2010) Selective inhibition of BET bromodomains. Nature 468 1067 PMID: 20871596
If you know of a relevant reference for (-)-JQ1, please let us know.
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关键词: (-)-JQ1, (-)-JQ1 supplier, inactive, analogs, negative, controls, bromodomains, BRD1, BRD2, BRD3, BRD4, Bromodomains, 5603, Tocris Bioscience
2 篇 (-)-JQ1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 (-)-JQ1 的部分引用包括：
Perry et al (2015) BET bromodomains regulate transforming growth factor-β-induced proliferation and cytokine release in asthmatic airway smooth muscle. Scientific Reports 290 9111 PMID: 25697361
Andrieu et al (2019) BET protein targeting suppresses the PD-1/PD-L1 pathway in triple-negative breast cancer and elicits anti-tumor immune response. Cancer Lett 465 45 PMID: 31473251
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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