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说明： HIF pathway activator
化学名： N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
纯度： ≥98% (HPLC)
生物活性 for ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM.
化合物库 for ML 228
ML 228 is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for ML 228
| 分子量 | 415.49 |
| 公式 | C27H21N5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1357171-62-0 |
| PubChem ID | 46742353 |
| InChI Key | QNRODODTMXCRKU-UHFFFAOYSA-N |
| Smiles | C1(C2=NC(NCC4=CC=C(C5=CC=CC=C5)C=C4)=C(C3=CC=CC=C3)N=N2)=NC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ML 228
参考文献 for ML 228
参考文献是支持产品生物活性的出版物。
Theriault et al (2012) Discovery of a new molecular probe ML228: an activator of the hypoxia inducible factor (HIF) pathway. Bioorg.Med.Chem.Lett. 22 76 PMID: 22172704
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关键词: ML 228, ML 228 supplier, ML228, hypoxia, inducible, factor, HIF, pathway, activators, iron, chelators, HRE, Hypoxia, Inducible, Factors, 4565, Tocris Bioscience
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