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ML 240

Cat. No. 5153 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： ATP-competitive inhibitor of p97 ATPase
化学名： 2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine
纯度： ≥99% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ML 240

ML 240 is an ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

化合物库 for ML 240

ML 240 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ML 240

分子量 396.44
公式 C23H20N6O
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1346527-98-7
PubChem ID 49830258
InChI Key NHAMBLRUUJAFOY-UHFFFAOYSA-N
Smiles NC1=NC4=C(C=CC=C4)N1C3=NC2=C(OC)C=CC=C2C(NCC5=CC=CC=C5)=N3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 240

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.93 20

制备储备液 for ML 240

以下数据基于产品分子量 396.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 12.61 mL 63.06 mL 126.12 mL
1 mM 2.52 mL 12.61 mL 25.22 mL
2 mM 1.26 mL 6.31 mL 12.61 mL
10 mM 0.25 mL 1.26 mL 2.52 mL

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参考文献 for ML 240

参考文献是支持产品生物活性的出版物。

Chou et al (2013) Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. ChemMedChem 8 297 PMID: 23316025

If you know of a relevant reference for ML 240, please let us know.

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关键词: ML 240, ML 240 supplier, ML240, ATP, competitive, inhibitors, AAA, ATPases, p97, VCP, valosin, autophagy, inhibits, Autophagy, Other, ER, stress/UPR, ATPase, Translocation, 5153, Tocris Bioscience

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