ML 7 hydrochloride

Name: ML 7 hydrochloride
Brand: Tocris Bioscience
SKU: 4310
Rating: 4.5 (2 reviews)

Cat. No. 4310 11 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of myosin light chain kinase

化学名： Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (11)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for ML 7 hydrochloride

ML 7 hydrochloride is a selective MLCK inhibitor (K_i= 0.3 μM). Exhibits more potent inhibition than ML 9 hydrochloride (Cat. No. 0431) Displays reversible, ATP-competitive inhibition of Ca²⁺-calmodulin-dependent and -independent smooth muscle MLCKs. Inhibits proplatelet formation and stabilization.

技术数据 for ML 7 hydrochloride

分子量	452.74
公式	C₁₅H₁₇IN₂O₂S.HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	110448-33-4
PubChem ID	9803932
InChI Key	KDDALCDYHZIZMH-UHFFFAOYSA-N
Smiles	IC1=C(C=CC=C2S(N3CCCNCC3)(=O)=O)C2=CC=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ML 7 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	22.64	50

制备储备液 for ML 7 hydrochloride

以下数据基于产品分子量 452.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.5 mM	4.42 mL	22.09 mL	44.18 mL
2.5 mM	0.88 mL	4.42 mL	8.84 mL
5 mM	0.44 mL	2.21 mL	4.42 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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产品说明书 for ML 7 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for ML 7 hydrochloride

参考文献是支持产品生物活性的出版物。

Saitoh et al (1987) Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J.Biol.Chem. 262 7796 PMID: 3108259

Meinders et al (2015) Sp1/Sp3 transcription factors regulate hallmarks of megakaryocyte maturation and platelet formation and function. Blood 125 1957 PMID: 25538045

If you know of a relevant reference for ML 7 hydrochloride, please let us know.

按标靶查看相关产品

关键词: ML 7 hydrochloride, ML 7 hydrochloride supplier, ML7, HCl, MLC, kinase, inhibitor, inhibits, myosin, light, chain, inhibitors, MLCKs, platelets, Myosin, Light, Chain, Kinase, 4310, Tocris Bioscience

11 篇 ML 7 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ML 7 hydrochloride 的部分引用包括：

Lee et al (2019) Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments. Nat Commun 10 529 PMID: 30705265

Chaudhuri et al (2015) Substrate stress relaxation regulates cell spreading. J Neurosci 6 6364 PMID: 25695512

Bharadwaj (2017) αV-class integrins exert dual roles on α5β1 integrins to strengthen adhesion to fibronectin. Nat Commun 8 14348 PMID: 28128308

Leoni et al (2015) Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest 125 1215 PMID: 25664854

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. Am J Physiol Renal Physiol 33 11206 PMID: 23825423

Nicoletta et al (2018) Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Cell 172 1063-1078.e19 PMID: 29474907

Robert D et al (2014) Eph-Ephrin signaling and focal adhesion kinase regulate actomyosin-dependent apical constriction of ciliary band cells. Development 141 1075-84 PMID: 24550115

William M et al (2022) Synaptopodin stress fiber and contractomere at the epithelial junction. J Cell Biol 221 PMID: 35416930

Clifford J et al (2019) Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development. Cell 179 90-105.e21 PMID: 31539501

Tharp et al (2018) Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab 27 602 PMID: 29514068

Ets (2016) Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca²⁺ Channels Does Not Involve Ca²⁺ Sensitization or Caldesmon. Front Pharmacol 7 516 PMID: 28082901

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ML 7 hydrochloride 的评论

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Works well.

By Wen Ding on 08/04/2020

分析类型： In Vivo

种属： Mouse

细胞系/组织： aorta

Mouse from all two groups were housed in condition of a 12 -h shift of light–dark cycle. Mouse of the control group were fed a normal diet, the ML7 group was fed orally treated with ML7 (1 mg/kg daily)

ML7 is good for polarization.

By Anonymous on 09/12/2019

分析类型： In Vitro