MLCK inhibitor peptide 18

Cat. No. 1885 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective inhibitor of myosin light chain kinase

别名： Myosin Light Chain Kinase Inhibitor Peptide 18

纯度： ≥95% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for MLCK inhibitor peptide 18

MLCK inhibitor peptide 18 is a selective competitive inhibitor of myosin light chain kinase (IC₅₀ = 50 nM). Displays 4000-fold selectivity over CaM kinase II and does not inhibit PKA. Cell permeable.

技术数据 for MLCK inhibitor peptide 18

分子量	1324.64
公式	C₆₀H₁₀₅N₂₃O₁₁
序列	RKKYKYRRK (Modifications: Lys-9 = C-terminal amide)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	224579-74-2
PubChem ID	10102940
InChI Key	JPOKAKNGULMYHZ-UILVTTEASA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for MLCK inhibitor peptide 18

溶解性	Soluble to 1 mg/ml in water

产品说明书 for MLCK inhibitor peptide 18

分析证书/产品说明书

化学品安全技术说明书

参考文献 for MLCK inhibitor peptide 18

参考文献是支持产品生物活性的出版物。

Lukas et al (1999) Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J.Med.Chem. 42 910 PMID: 10072688

Zolotarevsky et al (2002) A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease. Gastroenterology 123 163 PMID: 12105845

If you know of a relevant reference for MLCK inhibitor peptide 18, please let us know.

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1 篇 MLCK inhibitor peptide 18 的引用文献

引用文献是使用了 Tocris 产品的出版物。 MLCK inhibitor peptide 18 的部分引用包括：

Wang et al (2012) Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Proc Natl Acad Sci U S A 61 2134 PMID: 22688336

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