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说明： Selective inhibitor of Src and Syk
化学名： 3,4-Methylenedioxy-β-nitrostyrene
纯度： ≥99% (HPLC)
生物活性 for MNS
MNS is a selective inhibitor of Src and Syk tyrosine kinases. Inhibits thrombin-induced platelet aggregation via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism. Also inhibits inflammasome activation.
技术数据 for MNS
| 分子量 | 193.16 |
| 公式 | C9H7NO4 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1485-00-3 |
| PubChem ID | 672296 |
| InChI Key | KFLWBZPSJQPRDD-ONEGZZNKSA-N |
| Smiles | O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for MNS
参考文献 for MNS
参考文献是支持产品生物活性的出版物。
Wang et al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380 PMID: 16837624
Wang et al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601 PMID: 17601492
He et al (2014) 3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome. J.Biol.Chem. 289 1142 PMID: 24265316
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关键词: MNS, MNS supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, inhibits, inhibitors, Src, Syk, Adhesion, Molecules, Kinases, Kinase, Cell, Integrins, Inflammasomes, 2877, Tocris Bioscience
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