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Submit ReviewMps BAY 2a
说明： Potent and selective Mps1 kinase inhibitor
化学名： N-Cyclopropyl-4-[8-[(2-methylpropyl)amino]-6-(5-quinolinyl)imidazo[1,2-a]pyrazin-3-yl]benzamide
纯度： ≥98% (HPLC)
生物活性 for Mps BAY 2a
Potent and selective Mps1 inhibitor (IC50 = 1 nM for human enzyme). Selective for Mps1 over a panel of 220 kinases. Differentially inhibits human colon carcinoma cell proliferation. Blocks cell cycle progression by preventing spindle assembly checkpoint activation. Induces apoptosis.
技术数据 for Mps BAY 2a
| 分子量 | 476.57 |
| 公式 | C29H28N6O |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1382477-96-4 |
| PubChem ID | 57381882 |
| InChI Key | MDYKTGNHXNTATG-UHFFFAOYSA-N |
| Smiles | CC(C)CNC1=NC(C2=CC=CC3=C2C=CC=N3)=CN4C1=NC=C4C5=CC=C(C(NC6CC6)=O)C=C5 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Mps BAY 2a
参考文献 for Mps BAY 2a
参考文献是支持产品生物活性的出版物。
Jemaà et al (2013) Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 20 1532 PMID: 23933817
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关键词: Mps BAY 2a, Mps BAY 2a supplier, MpsBAY2a, monopolar, spindle, 1, kinase, Mps1, inhibitors, inhibits, cancer, proliferation, cell, cycle, assembly, checkpoint, apoptosis, inducers, Monopolar, Spindle, Kinase, Checkpoint, Control, Kinases, 5562, Tocris Bioscience
1 篇 Mps BAY 2a 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Mps BAY 2a 的部分引用包括：
Choi et al (2017) TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br.J.Pharmacol. 174 1810 PMID: 28299790
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该领域的文献
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.