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MR 24

Cat. No. 8122 Submit a Review Datasheet / COA / SDS
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Description: Potent and selective MST3 kinase binding inhibitor
Chemical Name: 8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
Purity: ≥98% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for MR 24

MR 24 is a potent and selective MST3 kinase binding inhibitor with >10 fold selectivity over MST4 (EC50 values from NanoBRET assay are 57 nM and 583 nM for MST3 and MST4 respectively). MR 24 increases the number of cells in G1 phase of cell cycle, is non-cytotoxic and cell permeable. Shows 90% stability over 1 hour in activated liver microsomes in vivo.

Technical Data for MR 24

M. Wt 618.38
Formula C26H29ClN6O3.3HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key GDJVKNSFYAPEKT-UHFFFAOYSA-N
Smiles CC1=CC=CC(C2=CC(Cl)=C(C3=CC(C=NC(NC(CO)CO)=N4)=C4N(CCCCN)C3=O)C=C2)=N1.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MR 24

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.92 50

Preparing Stock Solutions for MR 24

The following data is based on the product molecular weight 618.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.23 mL 16.17 mL 32.34 mL
2.5 mM 0.65 mL 3.23 mL 6.47 mL
5 mM 0.32 mL 1.62 mL 3.23 mL
25 mM 0.06 mL 0.32 mL 0.65 mL

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References for MR 24

References are publications that support the biological activity of the product.

Rak et al (2024) Development of selective pyrido[2,3.d]pyrimidin-7(8H).one-based mammalian STE20-Like (MST3/4) kinase inhibitors. J.Med.Chem. 67 3813

If you know of a relevant reference for MR 24, please let us know.

View Related Products by Target

Keywords: MR 24, MR 24 supplier, MR24, MST3, MST4, inhibitor, inhibitors, mammalian, STE20-like, protein, kinase, 3, STK24, ser, thr, ser/thr, Other, Kinases, Cell, Cycle, Inhibitors, 8122, Tocris Bioscience

Citations for MR 24

Citations are publications that use Tocris products.

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