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Mps1-IN-1 dihydrochloride

Cat. No. 5142 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective Mps1 kinase inhibitor
化学名： 1-[3-Methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-4-piperidinol dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Mps1-IN-1 dihydrochloride

Mps1-IN-1 dihydrochloride is a selective monopolar spindle 1 (Mps1) kinase inhibitor (IC50 = 367 nM); exhibits >1000 fold-selectivity against a panel of 352 kinases with the exceptions of ALK and Ltk. Disrupts the recruitment of Mad2 to kinetochores. Increases frequency of multipolar mitosis in U2OS cells.

External Portal Information for Mps1-IN-1 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Mps1-IN-1 is reviewed on the chemical probes website.

技术数据 for Mps1-IN-1 dihydrochloride

分子量 608.58
公式 C28H33N5O4S.2HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 1883548-93-3
PubChem ID 91691119
InChI Key HFJLUXGXTPNYTQ-UHFFFAOYSA-N
Smiles CC(C)S(C(C=CC=C3)=C3NC1=CC(NC4=C(OC)C=C(N5CCC(O)CC5)C=C4)=NC2=C1C=CN2)(=O)=O.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Mps1-IN-1 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 60.86 100
DMSO 60.86 100

制备储备液 for Mps1-IN-1 dihydrochloride

以下数据基于产品分子量 608.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.64 mL 8.22 mL 16.43 mL
5 mM 0.33 mL 1.64 mL 3.29 mL
10 mM 0.16 mL 0.82 mL 1.64 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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产品说明书 for Mps1-IN-1 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Mps1-IN-1 dihydrochloride

参考文献是支持产品生物活性的出版物。

Kwiatkowski et al (2010) Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat.Chem.Biol. 6 359 PMID: 20383151

Miduturu et al (2011) High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem.Biol. 18 868 PMID: 21802008

Lan and Cleveland (2010) A chemical tool box defines mitotic and interphase roles for Mps1 kinase. J.Cell Biol. 190 21 PMID: 20624898

If you know of a relevant reference for Mps1-IN-1 dihydrochloride, please let us know.

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关键词: Mps1-IN-1 dihydrochloride, Mps1-IN-1 dihydrochloride supplier, Selective, monopolar, spindle, 1, Mps1, kinases, inhibitors, inhibits, mitosis, Checkpoint, Control, Kinases, Monopolar, Spindle, Kinase, 5142, Tocris Bioscience

2 篇 Mps1-IN-1 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Mps1-IN-1 dihydrochloride 的部分引用包括：

Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33060198

Marc et al (2020) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathways. J Biol Chem 295 16906-16919 PMID: 33453946

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