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Submit ReviewMRT 68601 hydrochloride
说明： Potent TBK inhibitor
化学名： N-[3-[[5-Cyclopropyl-2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for MRT 68601 hydrochloride
MRT 68601 hydrochloride is a potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Inhibits the formation of autophagosomes in lung cancer cells.
技术数据 for MRT 68601 hydrochloride
| 分子量 | 487.04 |
| 公式 | C25H34N6O2.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1962928-25-1 |
| PubChem ID | 121513855 |
| InChI Key | BOBHGYDEKISHIZ-UHFFFAOYSA-N |
| Smiles | O=C(C1CCC1)NCCCNC2=C(C3CC3)C=NC(NC4=CC=C(N5CCOCC5)C=C4)=N2.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for MRT 68601 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 48.7 | 100 | |
| DMSO | 48.7 | 100 |
制备储备液 for MRT 68601 hydrochloride
以下数据基于产品分子量 487.04。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.27 mL | 20.53 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.11 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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产品说明书 for MRT 68601 hydrochloride
参考文献 for MRT 68601 hydrochloride
参考文献是支持产品生物活性的出版物。
Newman et al (2012) TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-κB signalling. PLoS ONE 7 e50672 PMID: 23209807
McIver et al (2012) Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKe kinases. Bioorg.Med.Chem.Lett. 22 7169 PMID: 23099093
If you know of a relevant reference for MRT 68601 hydrochloride, please let us know.
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Autophagy Scientific Review
Written by Patricia Boya and Patrice Codogno, this review summarizes the molecular mechanisms, physiology and pathology of autophagy. The role of autophagy in cell death and its links to disease are also discussed. Compounds available from Tocris are listed.
Autophagy Poster
Autophagy is a cellular process used by cells for degradation and recycling. Written by Patricia Boya and Patrice Codogno, this poster summarizes the molecular machinery, physiology and pathology of autophagy. Compounds available from Tocris are listed.
Pathways for MRT 68601 hydrochloride
NF-κB Signaling Pathway
NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.